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Changes of Claudin-4 in the Lung Tissues of Acute Hemorrhagic Necrotizing Pancreatitis Rats and Its Significances

Author: MengQingBin
Tutor: YiJiLin
School: Huazhong University of Science and Technology
Course: Surgery
Keywords: claudin - 4 Pancreatitis Lung injury Model
CLC: R576
Type: Master's thesis
Year: 2010
Downloads: 25
Quote: 0
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Abstract


Experimental Objective: To study claudin - 4 protein in acute hemorrhagic necrotizing pancreatitis (acute hemorrhagic necrotizing pancreatitis, AHNP) expression in rat lung tissue and its significance. MATERIALS AND METHODS: an experimental animals : health, male of Spraque - Dawley ( SD ) rats, 42 , provided by the Experimental Animal Center of Tongji Medical College of Huazhong University of Science and Technology . Two ways : (1) in accordance with the completely random , 42 Sprague-Dawley rats divided into sham group and AHNP of groups , each group of 21 rats . (2) injection of 5% sodium taurocholate solution retrograde cholangiopancreatography , induced AHNP model . Sham-operated rats abdominal cavity was opened , only flip the intestine , and then the abdomen was closed . (3 ) modeling operation is a success 12 hours later , the rats were sacrificed to collect the pancreas and lung specimens for pathological examination ; determination of lung wet weight, dry weight and the wet weight / dry weight ratio ; Western blot ( western blotting ) was detected lung tissue claudin - 4 protein expression . Results : acute hemorrhagic necrotizing pancreatitis rat pancreas and lung pathological damage ; compared with the sham group , acute hemorrhagic necrotizing pancreatitis rats lung wet weight / dry weight ratio was significantly higher ( P lt ; 0.01 ) , lung tissue claudin - 4 protein expression levels of significantly lower ( P lt ; 0.05 ) . Conclusion : AHNP rats were associated with significant lung injury , claudin - 4 expression downturn is likely in lung injury in AHNP rats in play an important role .

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CLC: > Medicine, health > Internal Medicine > Digestive and abdominal diseases > Pancreatic diseases
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