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The Effect of Treatment for Shenlijia Granijle on MMP - 2, TIMP - 2 and NF-κ B of the Chronic Heart Failure with Rats

Author: LiuWenBin
Tutor: JiangDeYou
School: Heilongjiang University of Traditional Chinese Medicine
Course: Clinical basis for TCM
Keywords: Force participation increases particle Matrix metalloproteinase-Ⅱ Matrix metalloproteinase inhibitorⅡ Nuelearfactor-κB
CLC: R285.5
Type: Master's thesis
Year: 2010
Downloads: 48
Quote: 0
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Abstract


Objective: To establish more consistent with the characteristics of congestive heart failure rat model of disease, observe the effects of preparation parameters force plus particles (from ginseng, Tinglizi, gracilistylus, March 7 and other drug components) on adriamycin induced heart failure large metabolism in rat myocardial injury and pathological changes, determine additional particles participate in force on heart failure model of the effect of myocardial injury and to analyze the role of the characteristics and possible mechanisms. Ability to participate in clinical practice to provide additional particle experiments and theoretical basis.Methods: By intraperitoneal injection of doxorubicin to explore animal model of chronic congestive heart failure, the replication method, particles were used to increase participate Drabanemerosa hebecarpa high, medium and low doses and in western medicine drugs, observing hemodynamics, myocardial pathological light and electron microscopy, immunohistochemistry staining for myocardial MMP-2, TIMP-2, NF-κB expression.Results: (1) by intraperitoneal injection of doxorubicin way, you can create more consistent with human chronic congestive heart failure in the Wistar rat model. (2) increase participation Drabanemerosa hebecarpa particles have improved hemodynamic indicators of heart failure in rats; reduce the pathological changes of myocardial cells, which serve the purpose of treatment of heart failure. (3) Participation Drabanemerosa hebecarpa particles can inhibit the heart failure increases myocardial tissue MMP-2, NF-κB over-expression increases the expression of TIMP-2.Conclusion: Participation Drabanemerosa hebecarpa add particles to some extent to improve hemodynamics in experimental heart failure in rats changes, reduce the pathological changes of myocardial cells and improve myocardial compliance, myocardial contractility increase the overall effect is obvious. Participation Drabanemerosa hebecarpa plus particles on myocardial protection in rats with heart failure, may regulate NF-κB, MMP-2 and TIMP-2 balance, stop, reverse ventricular remodeling and apoptosis, thereby reducing the target organ damage.

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology > Chinese medicine Experimental Pharmacology
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