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The Influence of Tongfu Decoction on CGRP in Lung and Intestine of Acute Lungn Injury Rats

Author: HaoZuoZuo
Tutor: LiZhuYing
School: Heilongjiang University of Traditional Chinese Medicine
Course: Chinese medicine
Keywords: Tongfu Decoction ALI CGRP
CLC: R285.5
Type: Master's thesis
Year: 2010
Downloads: 14
Quote: 0
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Abstract


Objective:To observe the effect on CGRP in ALI rat model lung and intestine, and to approach the mechanism of Tongfu Decoction anti-ALI, so to provide experimental base on the lung and the large intestine being interior-exteriorly related theory.Method:180 healthy wistar rats were choosed and randomly divided into six groups:the normal control group, the model group, hexadecadrol group, Chinese herbal medicine low-dose group, medium-dose group, and high-dose group,30 rats each group. Copying ALI model by caudal vein injecting LPS,giving respectively the Chinese herbal medicine intragastric administration and Dexamethasone intraperitoneal injection half an hour later,and executing rats in 1、2、6 hour after treatment respectively.10 rats each time in each group. We observed lung and intestine histomorphology changes, detected CGRP contene in lung and intestine by ELISA method synchronously.Result:1 Lung and intestine tissue in the model group showed dark red, turgent, bleeding by naked eye, but other treatment groups showed lighter than it.2 Lung and intestine tissue in the model group showed inflammatory cell infiltrate, edema, hyperemia, disorganization in light microscope, but other treatment groups showed lighter.3 CGRP content increased as time extending in first 6 hours in lung and intestine tissue of the model group.4 Lung and intestine tissue in ALI:CGRP contents in the model group were higher than the normal control group (P<0.05); contents in hexadecadrol group and Chinese herbal medicine groups were lower than the model group (P<0.05); contents in Chinese herbal medicine low-dose group were higher than hexadecadrol group (P<0.05); contents in Chinese herbal medicine medium-dose group and high-dose group showed lower than low-dose group (P<0.05); Chinese herbal medicine medium-dose group and high-dose group had no statistical significance (p>0.05).Conclusions:1 Tongfu Decoction could decrease CGRP in lung tissue of ALI rats model, The curative effects of high-dose and medium-dose group were better.2 Tongfu Decoction could decrease CGRP in intestine tissue of ALI rats model, The curative effects of high-dose and medium-dose group were better.

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