Dissertation > Excellent graduate degree dissertation topics show

The Role of 5-HT Involved in the Mechanism of Preventing Chemotherapy-induced Nausea and Vomiting of Forsythia Suspensain in Rat Pica Model

Author: WangJing
Tutor: NieKe
School: Shandong University of Traditional Chinese Medicine
Course: Chinese and Western medicine combined with the basis
Keywords: Forsythia Rats Cisplatin Chemotherapeutic pica 5-HT and 5-HT3A receptor
CLC: R285.5
Type: Master's thesis
Year: 2010
Downloads: 65
Quote: 0
Read: Download Dissertation

Abstract


Objective: The use of chemotherapy rat pica model to explore the role of 5-HT mechanisms the forsythia to chemotherapy nausea and vomiting . Method : different clinical commonly used chemotherapy drugs cisplatin rat pica model of rats was measured daily feeding kaolin amount as nausea and vomiting indicators . 72 hours after injection of cisplatin using HPLC- fluorescence detection method for determination of serum and brain tissue 5 - HT ,5 -HIAA content , using immunohistochemical method of brain and intestinal tissue 5-HT ,5-HT3A receptor the immunoreactive cell research . Results: We have successfully established a rat caused by cisplatin different food addiction model , experimental results show : (1) small perforatum extract in large doses and phillyrin could significantly inhibit the acute phase rat pica ( injection of cisplatin 0-24h), forsythia extract large doses can inhibit delayed rat pica ( 24- 72h after injection of cisplatin ) . (2) Compared with model group , perforatum extract in large doses and phillyrin have lower serum and brain tissue 5 - HT and 5-HIAA content trend , but no significant difference . ( 3 ) forsythia extract small , medium, large dose and phillyrin of a significant reduction in the expression of 5-HT3A receptors in rat brain tissue , and the results are superior to ondansetron . Perforatum extract large doses can significantly reduce the 5-HT content of rat intestinal tissue perforatum extract in large doses significantly lowered 5-HT3A receptor expression in rat intestinal tissue . Conclusion: forsythia acute and delayed chemotherapy nausea and vomiting have a significant preventive effect and its mechanism of action related to the lower 5-HT content in brain tissue and small intestine and down 5-HT3A receptor expression . The phillyrin is one of the active ingredients the forsythia involved antiemetic , prevent acute chemotherapy nausea and vomiting , and its mechanism may be related with lower 5-HT content down 5-HT3A receptor .

Related Dissertations

  1. Effects of CrPyr on Protein Metabolism in Rats,S865.12
  2. The Protective Effect of Rat Myocardial Ischemia/reperfusion Injury Following Bone Marrow Mesenchymal Stem Cell Pretransplantation for 1 Week,R542.22
  3. The Effects of Atorvastatin on Expression of Osteopontin in Kidney of the Diabetic Rats Its Molecular Mechanism,R587.2
  4. Meridians of Asthma Thread Burying Model Rats IL-4 Such Impact Experimental Study,R245
  5. The Study of the Effects of Isoflavones of Puerarin and Daidzein on Bone Metabolism in Ovariectomized Female Rats,R580
  6. Effect of Microwave on GAP-43 Expression in the Spinal Cord after Sciatic Nerve Lesions in Rats,R651.3
  7. The Expression and Mechanism of NF-κ B and IL-6 after 90% Portal Vein Ligation in Rats,R657.3
  8. Effects of Different Species Meats on Growth, Digestion Metabolism and Antioxidant Status in Rats,S865.12
  9. Effect of Grape Seed Procyanidins on the Blood Pressure in Renovascular Hypertensive Rats and Its Mechanism,R544.1
  10. The Research on Treatment of Lentivirus-mediated hVEGF-165 Gene Transferring Mesenchymal Stem Cells on Rat Hind Limb Ischemia,R329
  11. Experimental Study of Neural Stem Cells around the Lateral Ventricular Zone of the Hydrocephalus Rats,R742.7
  12. The Effect of RNA Interference-mediated ERCC1 Gene on the Chemo-treatment Sensitivity of NSCLC in Vitro,R734.2
  13. Clinical Observation Pemetrexed Combined with Cisplatin As First-line Treatment of Advanced Lung Adenocarcinoma,R734.2
  14. Anti-gout Capsules on the Treatment of Gouty Arthritis and Its Mechanism,R259
  15. Experimental Study of GUI QIN MISTURE on Adriamycin-induced Nephropathy in Rats,R285.5
  16. Effects of Losartan on Na~+, K~+-ATPase in Proximal Tubules Epithelial Cells of Spontaneously Hypertensive Rats,R544.1
  17. Influence of NF-κB Inhibitor (PDTC) on Protein Expression of ASPP1 and ASPP2 of Non-small Cell Lung Cancer,R734.2
  18. Influences of Cisplatin on Expressions of P-glycoprotein in the Resistance Cells of in Lung Cancer Xenografts in the Mice,R734.2
  19. Effect of Rh-Endostatin on the Expression of ERCC1 in Human Lung Adenocarcinoma A549 Cells,R734.2
  20. Influence on NF-κB P65 and ASPP2 of Murine Lewis Lung Cancer of NF-кB Inhibitor PDTC and Cisplatin,R734.2
  21. Low- dose cisplatin liver cancer stem cells enriched experimental study,R735.7

CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology > Chinese medicine Experimental Pharmacology
© 2012 www.DissertationTopic.Net  Mobile