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Using Grey Thinking to Establish the Technical Platform for Traditional Chinese Medicine Which Studied by Semi-bionic Extraction

Author: LiChao
Tutor: SunXiuMei
School: Shandong University of Traditional Chinese Medicine
Course: Of Pharmacy
Keywords: Cyperi after SFE-CO2 dregs Semi - bionic Extraction Molecular weight ≤ 1000Da extract Comprehensive Criteria Evaluation
CLC: R284.1
Type: Master's thesis
Year: 2010
Downloads: 57
Quote: 0
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Abstract


Objective: example to Cyperi, preparation of semi-bionic extraction (SBE) molecular weight to ≤ 1000Da extract the final product, to explore the basic ideas and models of Chinese medicines substances containing volatile ingredients of SBE. Method: ① first of Cyperi Pieces base source study of character identification and quality standards; ② in Cyperus rotundus supercritical fluid extraction conditions optimized on the basis of use the same Pieces, equipment, technical parameters for SFE-CO2 extraction, extraction matter other to save its dregs by uniform design to molecular weight ≤ 1000Da extract HPLC total area of ??indicators, the comprehensive evaluation, an optimal the SBE prepared by molecular weight to ≤ 1000Da extract conditions; ③ ethanol concentration 30% -80 % within the the proportional division method, the same indicators and evaluation methods, preferably Cyperi after SFE-CO2 dregs alcohol mentioned alcohol precipitation preparation of molecular weight to ≤ 1000Da extract the the better alcohol concentration; ④ same indicators and evaluation methods, the dregs 5 Ways the (SBE law, WE Act, AE method, SBAE law, WAE Act) molecular weight ≤ 1000 Da the Multiple Indicator ingredients of the extract compare; ⑤ chemical equivalents not necessarily biological equivalent pretending of the dregs extraction method molecular weight ≤ 1000 Da extract efficacy and toxicity comparison; ⑥ after the dregs Cyperus rotundus by SFE-CO2 extraction method molecular weight ≤ 1000Da extract the rabbit serum containing for HPLC fingerprint comparison; ⑦ extraction method molecular weight ≤ 1000Da extract rabbit serum containing rabbit isolated intestinal smooth muscle comparison Cyperus rotundus after SFE-CO2 dregs; the ⑧ final comprehensive evaluation analysis, the preferred The best extraction method and process conditions. Results: ① Cyperi conform one each under the provisions of the 2005 version of \, 9.0; extraction time is as follows: 2.0,1.0,1.0 h; (3) preferred half-the bionic extract the best alcohol precipitation concentration of 60%, the best alcohol extract concentration was 55%; the ④ Cyperi after SFE-CO2 drug slag 5 Ways molecular weight of ≤ 1000Da extract comprehensive index evaluation value order: YSBE gt; YAE gt; YWE gt; YSBAE gt; YWAE; ⑤ main pharmacodynamic experimental results show that the The 5 Ways molecular weight ≤ 1000Da extract to the strongest the SBE law Pharmacodynamics; acute toxicity experiments show, The 5 Ways molecular weight ≤ 1000 Da extract basic non-toxic; ⑥ Cyperi dregs ways after SFE-CO2 molecular weight to ≤ 1000Da extract its serum containing HPLC Fingerprint Comparison of the results shows that the total area of ??the characteristic peak SBE solution group; ⑦ 5 Extraction molecular weight to ≤ 1000Da extract containing serum, serum containing SBE in the strongest inhibition in vitro intestinal; ⑧ comprehensive evaluation results showed, and Cyperus rotundus extracted by SFE-CO2 dregs of SBE better. Conclusion: For Cyperi extraction, SFE-CO2 extraction of volatile and non-polar components extract the dregs reuse of SBE, the centrifugal - membrane filtration method molecular weight ≤ 1000Da extract; The SBE law ≤ 1000Da extract fluid containing serum extracted method (AE law, WE Act, SBAE law, WAE Act) ≤ 1000 Da extract corresponding comparison extract effective substances content of SBE strongest pharmacological effects. Therefore, Cyperus rotundus extraction Dregs again SBE extraction before SFE-CO2 extraction, better. This study Cyperi SFE-CO2 extraction after the dregs of SBE extraction and molecular weight ≤ 1000 Da extract the amount of the final product embodies the traditional Chinese medicine as a whole, comprehensive, objective, fuzzy, the unknown Chinese medicine effective substances Extraction expand the idea.

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Traditional Chinese medicine chemical > Chemical analysis and identification
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