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Objective: To investigate paeonol on experimental rabbit atherosclerosis atherosclerosis in rats and its possible mechanism . Methods: 36 healthy New Zealand rabbits were randomly divided into normal control group , model control group , the aspirin 30mg/kg/d group , paeonol low dose (37.5mg/kg/d) group , paeonol in dose (75 mg / kg / d) group , the paeonol high dose (150mg/kg/d) group . In addition to the normal control group , the rest of the group were given a high fat diet , and intragastric fat emulsion once a day. At the same time , a total of 12 consecutive weeks . Yu made ??before the model animal ear vein to take blood measured before modeling lipids ( TC , TG ) , the model 4 weekend retest TC , TG increased after each dose group in prey while modeling at the above doses orally treated with corresponding drugs , the normal control group, model control group was given the same volume of saline , once daily for 8 weeks . 8 weeks after drug administration , serum TC, TG, HDL-C, LDL-C, SOD vitality , MDA content was measured , taking plasma sICAM -1 were measured by ELISA of sVCAM- 1 , IL -6 , VEGF levels ; same time aortas pathological morphology . Results : paeonol reduce atherosclerotic rabbit serum TC , TG , LDL - C, MDA content, increased activity of SOD ; inhibition of plasma sICAM -1 of sVCAM- 1 , IL - 6 and VEGF expression ; paeonol the phenol can protect the morphological structure of the aorta . The Conclusion: Paeonol inhibit atherosclerosis formation , its mechanism of action and regulation of lipid metabolism disorders, reduce cytokine release , lipid peroxidation , and protect the vascular endothelium and so on .
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