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Studies on Pharmacodynamics and Anti-inflammatory Mechanism of Fuyankang Suppository

Author: DongQingQing
Tutor: HuangGuoJun
School: Chengdu University of Traditional Chinese Medicine
Course: Pharmacology
Keywords: Fuyankang Vaginitis Cervicitis Anti-inflammatory Analgesic Mechanism Prostaglandin E2 Vitamin C
CLC: R285
Type: Master's thesis
Year: 2010
Downloads: 103
Quote: 0
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Abstract


Objective: In this paper, effervescent suppository Fuyankang as the research object, the main research phenol slurry rats vaginitis, cervicitis therapeutic effect model and in vitro antibacterial kill Trichomonas vaginalis, inflammatory and analgesic effects play to the mechanism of the anti-inflammatory effect, to determine effervescent suppository treatment Fuyankang cervicitis, vaginitis efficacy of Fuyankang effervescent suppository provide reliable clinical pharmacology and its drug effective play to provide a basic proof. Method: This selection of phenol slurry rat vaginitis, cervicitis model, the use of in vitro antibacterial experiments in vitro killing Trichomonas vaginalis experiment, xylene the auricular inflammation caused by swelling experiments, capillary permeability in mice agar induced granulomatous experimental analgesic experiments, hot plate, acetic acid-induced writhing analgesic experiments to study Fuyankang treatment of vaginitis, cervicitis pharmacodynamic effects; phenol slurry and by measuring the copy the rat vaginal, the vaginal cervical tissue of the cervicitis model experimental animals PGE2 content; phenol slurry copy mice was measured vaginitis, cervicitis adrenal VitC, content, research Fuyankang Mi effervescent suppository anti inflammatory mechanism. Results: These pharmacodynamic experiments, of effervescent suppository Fuyankang phenol slurry copy of rats vaginitis, cervicitis has a significant therapeutic effect, performance on the rat vaginal, cervical mucosal inflammation Pathomorphological 11 detection indicators (the number of inflammatory cells, inflammatory cells, the sum of the areas) have different degrees of inhibition. From the pathological point of view, the rat vagina, cervix cavity exudate and shedding of epithelial keratosis has varying degrees of the different degrees of reduction in mucosal epithelial cell degeneration, necrosis and inflammatory cell infiltration, smaller, and promote vaginal, cervical inflammation tissue recovery, and thus play a protective effect on the vagina, cervix mucosa; vitro antibacterial role; vitro experiments show that killing vaginal trichomoniasis, a strong role in the killing of Trichomonas vaginalis . Significantly inhibited mouse ear edema (P lt; 0.05); abdominal cavity of mice induced by acetic acid inhibit increased capillary permeability; agar granuloma formation in mice inhibited; In hot plate method, the pain threshold in mice significantly increased role; writhing, the effervescent suppository Fuyankang can prolong the mice writhing incubation period, reducing the number of times of 20 minutes writhing . The experimental study of the anti-inflammatory mechanism, Fuyankang effervescent suppository inhibiting the inflammatory response and reduce the inflammatory tissue content of PGE2 and excitement hypothalamic - pituitary - adrenal axis related. Conclusion: Fuyankang is effervescent suppository rats copy of phenol slurry vaginitis, cervicitis have a therapeutic effect. Significant antibacterial, kill Trichomonas vaginalis, anti-inflammatory, analgesic effect. Through the study of the anti-inflammatory mechanism experiments show that the effervescent suppository anti-inflammatory mechanism of Fuyankang play and reduce vaginitis, cervicitis rat model of vaginal cervical tissue content of prostaglandin E2 and excitement hypothalamic - pituitary - adrenal axis function.

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