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Mulberry head The red (Sarcopyramis nepdensis) is the Melastomataceae (Melastomataceae) meat spike genus (Sarcopyramis) plants paper mulberry red head grass, Fujian folkloric herbal medicine widely used to treat a variety of acute and chronic hepatitis . To provide a scientific basis for the clinical application of the mulberry head red , the experimental system of mulberry head red the liver JiangMei activity and screened pharmacologically active site ; same time , we also carried out the chemical composition of the plant -depth research , lay the material basis for the pharmacological active ingredient screening . This study established the immunological liver injury Con A whole animal model of the red paper mulberry head ethanol extract and different polar fractions the liver JiangMei activity screening . By mouse serum AST , ALT , TNF -alpha , IFN -gamma , IL -6 and other indicators for the detection , indicating that the n-butanol portion , the water portion and the total paste extract all have a certain the liver JiangMei activity , wherein the total paste the liver JiangMei activity in a dose - dependent manner . The chemical composition of the system was the subject of the paper mulberry head full of red grass . Isolated in various parts of the 20 compounds were obtained : - stearate (Comp. 1), palmitic acid (comp. 3 ) 4 - ( 1 , 3 - propylene oxide ) -2 , 6 - dimethoxy yl - diphenyl ether (comp. 5), methylparaben (comp. 6 ) , 3 - methoxy-4 - hydroxybenzaldehyde (comp. 7 ) , cholesteric alkenylsulfinyl monooleate ( comp. 9), cholesteryl 17 ester (comp. 10 ) , 3 - [ (2E) -3 - (3 , 4 - dihydroxyphenyl - yl ) - acrylic acid ester -yl] -2, 19 - dihydroxy - ur Las -12 - 28-oic acid (comp. 12 ) , Arjunic acid (comp. 14 ) , caffeic acid (comp. 15 ) , oleic acid (comp. 16 ) , of β- sitosterol or alcohol (comp. 18 ) , carrots glycosides (comp. 20 ) , α - glucopyranose ( comp. 22) , β - pyran- glucose ( comp. 23) , 6 - ( 5 - acetoxy-1 , 2, 3 - trihydroxy-4 - A group - pentyloxy) -4 - hydroxy - 5 - keto -5, 6 - dihydride -4H-pyran -3 - carboxylate (comp. 24 ) , α -D - β ( 1 → 6 ) Portuguese disaccharide (comp. 25 ) -β-D - β ( 1 → 6 ) , Portugal the disaccharide (comp. 26 ) , α - 3- O -β - D - gluco - galactose - the D- A pentose (Comp . 27), α-3-O-β-D- pyran- galactose - the D- A pentose (Comp. 28). Wherein the Comp 5 , 24 is a new compound , except Comp. 1,3,18,20 , and the remaining compounds are first obtained from the separation of red mulberry head . Comp. 5,6,7,15,22,23,24,25,26,27,28 isolated from the active site of the monomer compound .
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