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Objective: To study innate drink renal vascular hypertension in rat kidney Smad3 and Smad7 expression . Methods: SD rats were randomly divided into normal group , sham operation group, operation group . Rats were adaptive feeding for a week , two - kidney - clamp method to copy a rat model of renal vascular hypertension , surgery group left renal artery folder narrow surgery under sterile conditions , and the sham group only separation of the left renal artery folder , the normal group without any treatment . Four weeks after the operation , modeling successful surgery rats were randomly divided into model group and innate drink group , born drink group given daily born drink gavage , model group , sham group and normal group to distilled water , sacrificed four weeks after intragastric administration of all animals , intraoperative before to eight weeks after surgery and consecutive nine manometry results . Collected blood when animals were sacrificed to send a biochemical laboratory tests BUN and CR with HE method to observe the morphological changes of the left kidney tissue , using Immunohistochemistry was used to detect the rat left kidney tissue in Smad3 and Smad7 expression . Results: The rats in model group and the normal group , sham group : elevated blood pressure , BUN and CR increased renal fibrosis of Smad3 expression amount raised of Smad7 expression down-regulated , the difference between the above groups have a significant statistical significance (P lt; 0.01); Having Treated around born , born to drink rats compared with model group : blood pressure decreased , but the difference was not statistically significance ( P gt ; 0.05) , BUN, CR decreases , the difference statistically significant ( P lt; 0.01 ) , reduce the degree of renal fibrosis , expression levels of Smad3 down of Smad7 expression levels increase , the difference between the groups was statistically significant ( P lt; 0.01 ) . Conclusion: born to drink to alleviate two of the kidney - clip renal vascular hypertension in rat renal fibrosis the efficacy mechanism may Smad7 expression by reducing the expression of Smad3 and promote .
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