Dissertation > Excellent graduate degree dissertation topics show

Of Guben phlegm Jiannao experimental study of the proposed AD dementia rat model of the role and mechanism .

Author: YouQiuYun
Tutor: WangPing
School: Hubei College of Traditional Chinese Medicine
Course: Basic Theory of Traditional Chinese Medicine
Keywords: Alzheimer’ s disease Ibotenic acid Model Behavioral science Cholinergic system
CLC: R277.7
Type: Master's thesis
Year: 2004
Downloads: 110
Quote: 0
Read: Download Dissertation


ObjectiveAlzheimer’ s disease(AD), named senile dementia, is a progressive neurodegenerative disorder with severe cognitive, behavioral, and functional impairment. Among a great deal of healing solution ,locus treatment is an important direction, but at present there are not the safe and effective medicine to resist AD . In the face of a large number of AD patients , It is very urgent and important to invent effective treatments. Traditional Chinese medicine has made great progress, so It is hopeful to use TCM to resist AD. Althouth its etiology is still unknown, it is generally accepted as related to the cholinergic deficit in the brain..In this paper, we determine the effects of Guben Huatan Jiannao Decoction (GHJD) on brain acetylcholinesterase(AchE) and acetylcholine(Ach) levels and behavioral science (Water maze test> Footshock avoidance test) in Alzheimer’ s disease (AD) rats, and analyze the mechanism of action of WDID for AD. MethodsLSD male rats were randomly divided into five groups as the operation group, AD model group, piracetam treated group, high-dose and low-dose of GHJD group.2. We used injection of basal nucleus of Meynert (BNM) with ibotenic acid(IBO) to make AD model. After treating for three weeks, channel water maze task and step-through task were used to observe the ability of learning and memory.3.We used reagent salver to assay the activity of acetylcholinesterase(AchE), and tissue chemistry method was used todetect, the content of acetylcho] ine(Ach) in hippocampus and corpusstriatum areas of brain.Results1. In the behavior experiment, not all the ability of learning gain , the significant differences were observed between control group, piracetam treated group , the high-, low-treated group of GHJD and AD model group(P<0. 01, P<0. 05).2. The activity of AchE was higher in AD model rats than that of control group .piracetam treated , and the high-, low-treated group of GHJD(P<0. 01).3. There was the remarkably improvement on the number of Ach in the three medicine groups(P<0.01 ) , and the activity of Ach in the high-treated group of GHJD was near to the level of control group(P<0. 01) . ConclusionsGuben Huatan Jiannao Decoct ion(GHJD) can improve the disability of learning and memory induced by ibotenic acid , and its effect maybe involve the activity of the Acetylcholine systym. Subject Word5

Related Dissertations

  1. EDM Electrode Wear Mechanism and Control Research,TG661
  2. Design and Research on Stabilization Loop of Gyro Stabilized Pod Control System,V241.5
  3. Satellite Attitude Control Methods Using Only Magnetorquers,V448.222
  4. Investigation of Turbine S2 Stream Surface Direct Problem Aerodynamic Optimization Design,V235.11
  5. The Research of Residential Community Design of Vanke Model,TU984.12
  6. The Equivalent Circuit Model of Radial Vibration Mode Piezoelectric Transformer and Its Application,TM406
  7. The Design and Accomplishment of Simulition Platform for Voltage Clamp Experiment Based on Cell Electrophysiological Model,R318.0
  8. High school politics,the new curriculum reform classroom teaching model to integrate exploration,G633.2
  9. The Software Component Modeling Method Based on Feature and Its Application in VMI Management System,TP311.52
  10. Development of Software Platform for Electro-Optical Test System,TP311.52
  11. Robust Model Predictive Control of Networked Systems,TP273
  12. Study on Development Risk Analysis and Management of Urban Commercial Residence,F293.35
  13. Development of the Chinese Version of the Marlowe-Crowne Social Desirability Scale and Its Correlation Research,B841.7
  14. The Research of Radiobiological Effect Mathematic Model Based on Equivalent Uniform Dose,R311
  15. The Study on Risk Evaluation of BOT Projects in China University,G647
  16. A Discussion on the Local Government’s Ethical Decision-Making,D625
  17. Research on University’s Energy Saving System Facing the Construction of Green University,G647
  18. The Research on Evaluation Method of Highway Ecosystem Healthy,X826
  19. Research on the Regional Difference and Influence Factors of China’s Carbon Emissions,X502
  20. Genetic Segregation Analysis and QTL Mapping as Well as Association Analysis for Panicle Angle Trait in Japonica Rice (Oryza Sativa L.),S511.22
  21. Research of Graduates’ Educational Satisfactory Evaluation in Heilongjing Province Based on LISREL Model,G643

CLC: > Medicine, health > Chinese Medicine > Chinese medicine practitioners of other disciplines > TCM neurology and psychiatry
© 2012 www.DissertationTopic.Net  Mobile