Dissertation > Excellent graduate degree dissertation topics show

Association Analysis of LPIN1 Gene Snps with Economic Traits in Cattle

Author: WeiLiXuan
Tutor: LeiChuChao
School: Northwest University of Science and Technology
Course: Animal Genetic Breeding and Reproduction
Keywords: Bovine LPIN1 gene Polymorphisms Economic Traits Correlation Analysis
CLC: S823
Type: Master's thesis
Year: 2011
Downloads: 31
Quote: 0
Read: Download Dissertation

Abstract


Identification of the genes and polymorphisms underlying quantitative traits, and understanding how these genes and polymorphisms affect economic traits, are important for successful marker-assisted selection and more efficient management strategies in commercial cattle populations. One of the lipin protein family, Lipin1 protein affect the body fat is encoded by LPIN1 gene.LPIN1 gene affect fat development by two ways, one is participate the fat development by the Lipin1 protein which is it encoded; another way is inductive effects, inductive the genes that association with fat development.Genetic polymorphism of LPIN1 gene were detected by PCR-SSCP, PCR-RFLP and DNA sequencing in 740 samples from six cattle populations(Caoyuan red cattle, Qinchuan cattle, Jiaxian red cattle, Luxi cattle, Xianan cattle and Nanyng cattle),and association analysis were carried out by SPSS ware. The purposes of study are to discovery polymorphisms and select molecular markers with significant on growth traits in Chinese cattle, to provide genetic information for molecular breeding in beef database. The research results as follows:The results showed that there were 4SNPs in the LPIN1 gene: g.438C>T, g.31735A>G, g.46137A>C and g.65969G>A, and they located in the UTR, the intron 1, exon 6 and intron 15 respectively, of which 46137A>C was a missense mutation. Association analysis of polymorphisms with economic traits in 260 Qinchuan cattle showed that, the individuals with genotype TT are significantly related to Heart depth, and Heart girth at g.438C>T locus (P<0.05); the individuals with genotype GG are significantly related to Heart depth, Backfat thickness and Heart girth at 31735A>G locus (P<0.05); the individuals with genotype AC and CC are significantly related to Backfat thickness, and the genotype CC is significantly related to the Loin muscle area and Backfat thickness at 46137A>C locus (P<0.05); the individuals with genotype AA are significantly related to the Loin muscle area, Heart depth, Heart girth and Backfat thickness (P<0.05), and the individuals with genotype GG are significantly related to Marbling score (P<0.05) at 465969G>A locus respectively. We conclude that LPIN1 gene may be closely related to the meat quality traits, such as Loin muscle area, Backfat thickness and Marbling score, and it could be as a candidate molecular marker utilized in breeding strategy for Qinchuan cattle.

Related Dissertations

  1. The Distribution Characteristics of Osmiophilic Granules in Tobacco Leaves at Different Altitudes and the Relationship with the Quality of Flue-cured Tobacco Leaves of Huili,S572
  2. Analysis on Characteristics and Discriminant of Aroma Types of Flue-Cured Tobacco,S572
  3. Evaluation of Photosynthetic Efficiancy of Seedlings of the Hybrid Progenies (F1) in Peach,S662.1
  4. Children with acute leukemia also prototype folate carrier gene polymorphism,R733.71
  5. The Association of the Intron 4 Loci Variable Number of Tandem Repeat (VNTR) Polymorphisms of NLRP3 Gene with Gout and Hypertension,R544.1
  6. Numerical Simulation on Blasting Cavity and Experimental Study of Grouting for Supporting in Soil,F416.22
  7. Assessment of Aquatic Ecosystem Function of Liao River Basin and Identification of the Major Factors,F224
  8. The Study of Association between Clock Gene T3111C and T257G Polymorphisms and Sleep Epilepsy in a Hunan Han Population,R742.1
  9. Study on Processing Functionalities and Application of Bovine Plasma Proteins,TS251.1
  10. Study of Population Genetic Structure of House Mouse MUS MUSCULUS CASTANEUS in Shanghai,Q953
  11. Chloroplast DNA Phylogeography of Subgenus Soja in China,Q943
  12. Preparation of Egg Yolk Antibodies Against Bovine Viral Diarrhea Virus (BVDV) and Research the Activeness to Neutralize Virus,S852.65
  13. Clay minerals study load of bovine serum albumin,P642.1
  14. Alpine mountains of northwestern Yunnan land-use change and socio-economic development of the relationship,F127;F224
  15. Research of Capital Influence to FDI,F832.6
  16. Research on the Evaluation Index System of Tourism Real Estate Investment Environment,F293.3
  17. Uncertain reasoning algorithm of fuzzy rule - based matrix transform,TP18
  18. Factors associated with coronary heart disease and Decision Tree Analysis Syndromes Distribution of Application,R259
  19. Uygur , Han population MTHFR C677T polymorphism genetic epidemiology,R394
  20. Correlation between Coronary Artery Disease and the Level of Serum Lectin-like Oxidized Low-density Lipoprotein Receptor-1 and Its Polymorphism,R541.4
  21. Association of Genetic Polymorphism in Brain Natriuretic Peptide with Essential Hypertension in Hunan Han,R544.1

CLC: > Agricultural Sciences > Livestock, animal medicine,hunting,silkworm,bee > Livestock > Cow
© 2012 www.DissertationTopic.Net  Mobile