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Synthesis and Biological Activity of Solanesyl Triamines

Author: WangJianHong
Tutor: WangChaoJie；ZhaoZuo
School: Henan University
Course: Polymer Chemistry and Physics
Keywords: Solani farnesyl piperazine triamine derivative Synthesis Physiological activity Coenzyme Q0
CLC: O621.13
Type: Master's thesis
Year: 2005
Downloads: 70
Quote: 1
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Abstract


This article is mainly engaged in the the eggplant farnesyl triamines Synthesis and physiological activity of. On this basis, the synthesis of the asymmetric polyamine skeleton, a preliminary exploration. 8 intermediates and 16 target product of 24 unreported new compounds were synthesized, the structure of these compounds were confirmed After ~ 1HNMR, IR, MS and elemental analysis; tested four kinds of tumor cells in vitro to the target compound inhibition rate spectrometry analysis of the mode of action of some target compounds with DNA. Also discussed Coenzyme Q0 synthesis process. I. Introduction solanesol derivatives, especially eggplant farnesyl amine derivatives Synthesis and physiological activity of the present situation and prospects of the research and the research of polyamine compounds Li title basis. , Eggplant Synthesis and physiological activity of the piperazine alkyl amines research 2.1 eggplant piperazine alkyl amides Derivatives 2.2 eggplant piperazine alkyl amine derivatives synthesis of the 2.3 target compounds physiological activity test and interaction with DNA Spectroscopy Institute of Materia Medica, Chinese Academy of Medical Sciences, the National Drug Screening Center, part of the target compounds for four kinds of cancer cells (KB: human oral epithelial cancer; Bel-7402: people hepatoma cells; A-549: human lung cancer cells; the MDA: breast cancer cells) in vitro physiological activity of the test, the results show that the eggplant Triamine Bel-7402 cells inhibition rate than the three commercial drug (5-Fu, Bpa Npa) is slightly higher, but on KB cells and A549 cells opposite. 4, respectively, and 5-fluorouracil, Bpa, Npa coupled to 5-Fu eggplant piperazine alkyl amide 8 inhibitory activity of most improved, and the containing the Bpa of the amide 9, 10 pairs of the amide containing Npa measuring the inhibitory rate is generally reduced; 4 with a benzene ring, a naphthalene ring, an anthracene ring, after coupling, respectively, a benzene ring-containing eggplant piperazine alkylamine. 15A, 15b of the inhibitory activity of the majority of improved, especially 15b on the A549 and Bel-7402 cell activity has increased, while the two cell inhibitory activity decreased 15c. Inhibitory activity containing naphthalene ring 16b and 15b are similar but relatively low, of 16a containing naphthalene and anthracene ring 17a, 17c of the measured cell inhibition rate is generally lower. Meanwhile, the part of the target compound is tested on salmon sperm DNA role UV, FL, the spectrum, indicating that the combination of the mode of action of these compounds with DNA and atypical ditches, but more demonstration of similar non-ionic surface active agent , we hypothesized that its combination may be only electrostatic binding or binding portion embedded. Three, asymmetric preliminary synthesis of three amine compound.

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CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Organic Chemistry general issues > Theory of organic chemistry,physical organic chemistry > Organic Chemistry Structure Theory
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