|
Introduction diabetes , obesity , dyslipidemia , hypertension coexist by some scholars known as insulin resistance (ISR) syndrome , insulin resistance is a common basis for a variety of metabolic disease , always throughout with type 2 diabetes . Improve in patients with type 2 diabetes , insulin resistance become the key to the treatment of this disease and prevent its complications . Propylene glycol alginate sodium (PSS) has anti-clotting , reduce blood viscosity , blood fat and improve microcirculation role , have a better effect on ischemic heart and cerebrovascular disease, and hyperviscosity , hyperlipidemia . Since the 1990s , PSS began to be applied to the study of diabetes and its complications . Clinically proven PSS can significantly improve type 2 diabetes associated with abnormal lipid metabolism in patients with hyperlipidemia , improve insulin resistance , although the PSS has been used clinically for many years , but its pharmacological mechanism of action has still not very clear , to further clarify its possible the mechanism requires reliable technical means of animal models and related data and molecular biology . The purpose of this experiment the the prey of hyperlipidemia in type 2 diabetic rat model of their lipids, glucose, insulin resistance , and histological observation PSS explore the drug in the pharmacological effects and possible mechanisms of the animal model , and to further clarify the PSS the mechanism of action provides a reliable animal data and research tools . Materials and Methods , the animal model and the grouping scheme : 48 Wistar rats were randomly assigned to six groups : control group ( control ) , model group ( DM ) , the PSS group is divided into low- dose (PSS 30mg · kg -1 ), medium dose (PSS 90mg · kg -1 ), high
|