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Preliminary Observation of the Effect of Hyperoxic Ringer’s Solution on the Rabbits and Patients with Inhalation Injury at Early Post-burn Stage

Author: HuangLiFeng
Tutor: JiaChiYu
School: Fourth Military Medical University
Course: Surgery
Keywords: inhalation injury Hyperoxic ringer’s solution
CLC: R644
Type: Master's thesis
Year: 2005
Downloads: 19
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Abstract


ObjectiveTo investigate the effects of hyperoxic Ringer’ s solution on the rabbits and patients with inhalation injury at early post-burn stage.Methods① The rabbit models of severe smoke inhalation injury were established according to the methods reported by Burn Institute of the Third Military Medical University. 77 rabbits were randomly into four groups, i. e. A group （normal, n=5）, B group （with Ringer’ s solution treatment, n=24）, C group （with hyperoxic Ringer’ s solution treatment, n=24） and D group （without treatment, n=24）; in B、 C、 and D groups.② The indexes which we detected at the ld、 2d、 3d、 5d、 7d、10d after injury were as follows: the vital signs , blood gas analysis, measure of WBC and PMN in the peripheral blood, ratio of wet weight/dry weight （W/D） of the lung tissue, the detections of MDA、 SOD、 MPO in the lung tissue and the total protein concentration in the peripheral blood, the total protein concentration and the NE concentration in BALF , the pulmonary microvascularpermeability and analysis of pathology in the lung.（3） Eight patients with over 30% TBSA and moderate inhalation injury were randomly enrolled in the study（+）, while other 4 cases with similar conditions as control（-）. Intravenous infusion of 1500ml hyperoxic Ringer’ s solution were given to the patients every day and for 7 days in the former group,while equal amount of Ringer’ s solution was given to the patients in the control group.The vital signs,the blood biochemical indices and the blood gas analysis of the two groups were monitored dynamically.Results① inhalation injury often induced metabolic acidosis and respiratory acidosis.②The indexes of PaCO2、 WBC、 PMN、 W/D 、MDA、 MPO, the total protein concentration and the NE concentration in BALF,the pulmonary microvascular permeability index inB. C and D groups were higher than those in A group, the sequence was as follows: D group>B group>C group>A group; and the indexes of PH、 PaO2、SOD in injury groups were decreased than those in A group, the sequense was as follows: D group<B group< C group<A group.③ Changes of pathology: augment of the lung’ s solidity and inflammation were occurred in the lung tissue in injury groups, the extent and degree of these lesion were decreased after the treatment of hyperoxic Ringer1 s solution.④ The vital signs of the patients in group T were steady with slight changes in the blood biochemical indices when compared with those in group C,while the level in PaO2 was significantly higher than that in group C.

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CLC: > Medicine, health > Surgery > Traumatology > Burns and scalds ( burns )
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