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Research Advancement of Gynecological Blood Stagnation and the Experimental Research of Effect Which Blood Activating and Stasis Removing Leads to the Blood Stasis Rat-Model

Author: LuoHuanHuan
Tutor: DengGaoZuo
School: Guangzhou University of Traditional Chinese Medicine
Course: Chinese Gynecology
Keywords: Stasis syndrome Blood circulation Mechanism of action / animal studies E2, P, E2R, PR, ca2 changes
CLC: R271
Type: Master's thesis
Year: 2005
Downloads: 369
Quote: 2
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Abstract


Purposes of articles aimed at the common gynecological disease through extensive and in-depth study blood stasis syndrome clinical and experimental research progress of literature's role in the mechanism of the formation mechanism of gynecological blood stasis and promoting blood circulation method, as well as gynecological blood stasis Therapeutic Governing Law and other content summary and discussion, and provide a theoretical basis for animal experiments. Medium-length through the establishment of blood stasis rats model aims to observe the the stasis model rat of E2, P, E2R, PR, Ca 2 , hemorheology, uterine and ovarian morphology school changes, as well as blood circulation stasis model rats the impact of the above factors change, to further explore the mechanism of the stasis syndrome the mechanism of the formation of blood circulation herbs. Methods papers through an extensive inspection of the literature of the common gynecological stasis syndrome Clinical and Experimental Research, and related literature in-depth study and summarize. Novella conducted animal studies: 40 SD rats were divided into four groups, the blank control group (A), model group (B), the model Yunnan Baiyao group (C), model Gongxueting group (D), 10 in each group. Normal saline, respectively, Yunnan Baiyao Gongxueting decoction orally. Completion of the last administration, the latter three groups made blood stasis model, after 20 hours, the blood and the uterus, ovaries, and blood rheology, serum E2, P levels, uterine, ovarian E2R, PR, serum Ca 2 content, uterine, ovarian slices HE staining observed. The results contrast, T-test and variance analysis comparative data significant differences between groups. The results of the literature study found: 1, gynecological blood stasis generated mainly due to the following reasons: ① hemorheology science, hemodynamic changes. ② local microcirculation and organizational structure change. (3) changes in hormone levels of the endocrine system. ④ the functional status of the body's immune system disorder. ⑤ trace elements (particularly Zn, Cu) content changes. Blood circulation treatment of gynecological blood stasis mechanism mainly the following aspects: ① estrogen. ② Key Indicators improve blood rheology, improve the microcirculation of the uterus. ⑨ regulating coagulation system, fibrinolytic system function. The ④ protect vascular endothelial cells and their functions. ⑤ significant inhibition of uterine smooth muscle contraction. ⑥ analgesic effect. ⑦ anti-inflammatory effects. ⑧ enhance immune function. The ⑨ sedation. Treatment of gynecological blood stasis: ① Differential Treatment is most commonly used is the most basic method, empirical devaluation (cell) blood warm through law, as well as qi and blood circulation method, the deficiency in the most commonly used for the kidney and activating blood method. Also emphasized in the treatment of bleeding disorders of the blood stasis syndrome stasis to stop bleeding. (2) other treatments, the cycle of therapy such as endometriosis, chronic pelvic inflammatory disease, tubal obstruction infertility permit comprehensive treatment has a significant effect. Medium-length experimental findings: stasis model group compared with the blank control group, E2, P was significantly lower (P lt; 0.01), serum Ca 2 value was significantly higher (P lt; 0.05) E2R PR positive degree of no significant change (P gt; 0.05), hemorheology showed significantly higher (P lt; 0.01), ovarian qualitative and proliferative phase endometrium apparent blood stasis card pathological changes, and no significant changes in blood stasis syndrome pathology secretory endometrium. The two treatment groups compared with stasis model group, E2 levels rebounded significantly (P lt; 0.01), P (progesterone) values ??upward trend (P gt; 0.05), serum Ca 2 value further significantly increased (P7 lt; 0.05), E2R, PR Yang

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