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The Laboratory Study of Autologous Blood Transfusion on Abdominal Continuous Hemorrhagic Shock

Author: WangBo
Tutor: ZhangJinGang；ZhouHong
School: PLA Military Academy of Medical Sciences
Course: Immunology
Keywords: Autologous blood transfusion Hemorrhagic shock Dog
CLC: R605.971
Type: Master's thesis
Year: 2005
Downloads: 63
Quote: 0
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Abstract


Hemorrhagic shock is an important cause of death in war wounds, blood transfusion is the most important measure to solve this problem. The allogeneic blood there is always the potential of allogeneic transfusion reactions, blood-borne disease transmission reported blood supply and transport difficulties and allogeneic blood transfusion, which are affecting battle injury hemorrhagic shock treatment effect. Autotransfusion is an effective method to solve this problem has developed rapidly in recent years, it can reduce the use of exogenous blood volume, to avoid many of the problems caused by the allogeneic blood transfusion. But its use is restricted autologous blood recovery system volume is too large, and the presence of contraindications. War conditions of hemorrhagic shock caused by trauma, blood will inevitably be pollution and improve the processing power of autologous blood recovery machine contaminated blood for autologous blood transfusion technology for the treatment of war wounds hemorrhagic shock is essential. For these reasons, the selection of new 3000P autologous blood recovery, study of autologous blood reinfusion of wartime hemorrhagic shock treatment for the continuous war hemorrhagic shock treatment characteristics. In this experiment, Wiggers law basis of canine abdominal injury continuous hemorrhagic shock model, shock shock dogs after infusion of Ringer's solution treatment (control group) and shock after reinfusion of autologous blood treatment (experimental group) and blank group does not give and treatment. The animals were observed survival time, the physiological indicators, red blood cells of the index, platelet count, and animal organs (heart, liver, lung and kidney) biopsy. The results show that, compared with the control group, the shock reinfusion from the body and blood of animals of the treatment group survival time was significantly longer (P lt; 0.05) of the index of the red blood cells in the blood to maintain good organ injury is significantly reduced. Autologous blood transfusion significant treatment effect of continuous abdominal hemorrhagic shock. Further study of the processing capacity of autologous blood back to the input technology of contaminated blood, we open the ascending colon on the basis of the model, take the intestinal contents were, mixed into the blood, the use of self-body blood recycling machine 250ml of contaminated blood with 500 ml of 1000ml and 1500 ml of physiological saline and washed, and after washing the blood of broad-spectrum antibiotics, antibacterial treatment. Contaminated blood, different amounts of saline washed the blood and composite antibiotics washed blood the LB plate culture, observed the growth of bacteria. The results showed that blood contaminated by intestinal contents after autologous blood recovery machine processing, the number of bacteria in the blood a significant reduction in the clinical doses of antibiotics added to 1500 ml of normal saline washed blood, bacterial growth was completely inhibited.

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CLC: > Medicine, health > Surgery > Surgical Therapy > Emergency Surgery > Surgical shock
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