Dissertation > Excellent graduate degree dissertation topics show

The Differences and Clinical Significance of Expression of Glutathion-S-Transferases-Π and Topoisomerase IIΑ in Different Parts of Oral Squmous Cell Carcinoma

Author: SunZhaoYao
Tutor: ZhuoXiaYang
School: Jiangxi Medical College
Course: Oral pathology
Keywords: Multidrug resistance The Valley light Gan peptide -S- transferase -π Topoisomerase II Heterogeneity
CLC: R739.8
Type: Master's thesis
Year: 2005
Downloads: 24
Quote: 0
Read: Download Dissertation

Abstract

Objective: divided into different areas by surgical resection specimens of oral squamous cell carcinoma study different regions of the resistance gene product of GST- pi , Topo IIα expression differences , explore the differences in different areas of resistance in oral squamous cell carcinoma and clinical significance . Methods : 20 patients without chemotherapy and 19 patients after induction chemotherapy for oral squamous cell carcinoma of the paraffin-embedded specimens using immunohistochemical methods to detect sub- surface area and deep infiltration area observed the expression of GST-π, Topo IIα . Flow cytometry and immunohistochemistry detected five cases without chemotherapy fresh oral squamous cell carcinoma specimens surface area and deep infiltration area to observe the expression of GST-π, Topo IIα . Results: 20 cases without chemotherapy oral squamous cell carcinoma of the surface area of GST- pi , Topo IIα positive expression were 18 cases (90%) , 15 (75% ) patients ; deep infiltration area GST-π, Topo IIα positive expression were 15 cases (75% ) 1 (5 %) patients . 19 patients with induction chemotherapy oral squamous cell carcinoma of the surface area of GST- pi , Topo IIα positive expression were 16 cases (84.21%) , 18 cases (94.74 %) ; deep infiltration area GST-π, Topo IIα positive expression were 12 cases ( 63.16% ) , 8 cases ( 42.11% ) . GST-π, Topo IIα expression in the surface area and the deep zone has a significant difference P lt ; 0.05. In the presence or absence of chemotherapy between the two samples , GST-π positive expression of the tumor deep infiltration area significant difference in the expression of tumor surface area and the deep zone , TopoIIα there were significant differences in P lt ; 0.05 . Flow cytometry was detected five cases of fresh TopoIIα positive cells without chemotherapy oral squamous cell carcinoma of the GST -π percentage of the total number of cells : the surface area GST - π TopoII α were 3.676% , 4.656% : the deep infiltration area GST - π, Topo IIα respectively 5.586% , 3.482% , respectively . Immunohistochemical detection technology detected in 5 cases the fresh without chemotherapy oral squamous cell carcinoma of the GST -π , Topo IIα positive cells in the percentage of the total number of cells : the surface area GST - π TopoII α were 45.176% , 9.958% : The deep infiltration area of GST- π TopoIIα 19.148% and 4.626% . Flow cytometry GST-π, TopoIIα, each in

The Differences and Clinical Significance of Expression of Glutathion-S-Transferases-Π and Topoisomerase IIΑ in Different Parts of Oral Squmous Cell Carcinoma

Abstract

Related Dissertations