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Combined Effect of Clarithromycin and Gatifloxacin on Pseudomonas Aeruginosa Biofilms in Vitro

Author: XiaoShengPing
Tutor: WenGuiLan
School: Jiangxi Medical College
Course: Respiration within the science
Keywords: Clarithromycin Gatifloxacin Biofilm The minimum biofilm Clear concentration
CLC: R96
Type: Master's thesis
Year: 2005
Downloads: 74
Quote: 1
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Abstract


Objective To study the clarithromycin and gatifloxacin in combination in vitro against Pseudomonas aeruginosa biofilm ( biofilm , BF ) . By modified plate culture method to establish BF in vitro model , different concentrations of clarithromycin role , scanning electron microscopy (Scanning electron microscope, SEM) observation and measurement of the role of different concentrations of clarithromycin group Gatifloxacin the lowest concentration of biofilm removal (Minimal biofilm eradicate concentration, MBEC). Biofilm morphology observed 1/4 minimum inhibitory concentration ( MIC ) , 1/16 MIC of clarithromycin role group BF cellulose-like material and glue markedly reduced ; compared with unused clarithromycin , 1/4MIC MBEC value of 1/16 MIC the clarithromycin role group plus gatifloxacin significantly reduced ( P lt ; 0.05 ) . Conclusion clarithromycin against Pseudomonas aeruginosa having no bactericidal activity , but 1/4MIC 1 / 16 MIC clarithromycin can reduce Pseudomonas aeruginosa BF cellulose-like substance to destroy the structure of the biofilm , increase gatifloxacin antibacterial activity .

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