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The Applied Research of MR Spectroscopy in Prostate Cancer

Author: JiangJian
Tutor: GongHongHan
School: Jiangxi Medical College
Course: Medical Imaging and Nuclear Medicine
Keywords: Proton magnetic resonance spectroscopy Multi-voxel Prostate cancer Classification Prostate-specific antigen
CLC: R737.25
Type: Master's thesis
Year: 2005
Downloads: 65
Quote: 3
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Abstract


Objective: magnetic resonance spectroscopy method of quantitative evaluation of prostate cancer metabolism , evaluation of magnetic resonance spectroscopy ( MRS ) in the diagnosis of prostate cancer ( PCa ) and differential diagnostic value . Methods: 30 patients with benign prostatic hyperplasia and 23 patients with prostate cancer MR and MR spectroscopy examination . MR conventional scanning sagittal T2-weighted , axial T2 -weighted , fat suppression T2-weighted and axial T1-weighted . As measured metabolites including CIT , Cho, Cr . Serum PSA testing , using a Beckman automatic chemiluminescence immunoassay analyzer and its corresponding kit . Statistical analysis using SPSS V12 professional statistical software , single-factor analysis of variance, different are any two of t test was used . Results: All 53 cases subjects underwent a multi - voxel spectroscopy scan ( in 23 patients with prostate cancer , Gleason II level 3 cases , 12 cases of Gleason grade III , 6 cases of Gleason grade IV , Gleason grade Ⅴ two cases ) . Patients with benign prostatic hyperplasia , prostate cancer Cho value as follows : patients with benign prostatic hyperplasia 1.27 ± 0.42 , prostate cancer 3.22 ± 1.12 Cho value of the group of benign prostatic hyperplasia and prostate cancer group Cho value there is a significant difference ( P lt ; 0.05 ) ; Cit values ??between the groups were benign prostatic hyperplasia group , 3.68 ± 0.98 , prostate cancer group 0.54 ± 0.32 , values ??of benign prostatic hyperplasia group Cit prostate cancer Cit value there is a significant difference ( P lt ; 0.05 ) ; Cr values ??between the groups were prostate hyperplasia group 0.77 ± 0.06, 0.74 ± 0.10 , prostate cancer . No significant difference between the groups Cr . Between the CHO Cr / Cit value prostatic hyperplasia group 0.58 ± 0.15 , 10.64 ± 10.09 prostate cancer , benign prostatic hyperplasia group Cho Cr / Cit value of the prostate cancer group Cho Cr / Cit value significant difference ( P lt ; 0.05 ) ; Cho / Cr values ??between the groups were benign prostatic hyperplasia group , 0.37 ± 0.12 ; prostate cancer group 8.54 ± 8.41 . Prostatic hyperplasia group with prostate cancer group, a significant difference ( P lt ; 0.05 ) The Gleason the II grade III Cho value Cit value of 3.42 ± 1.01 0.67 ± 0.31 Cho / Cr value of 4.37 ± 1.25 Cho Cr / Cit in the prostate cancer group

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CLC: > Medicine, health > Oncology > Genitourinary tumors > Male genitalia tumors > Prostate cancer
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