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Objective: vascular dementia (VD) is intelligent clinical and cognitive dysfunction syndrome caused by cerebrovascular diseases . Clinical manifestations associated with cerebrovascular disease and dementia characterized . Chinese medicine treatment of VD has a wealth of practical experience in delaying disease progression and improving patients with systemic symptoms , to some extent, improve intelligent state such as the performance of the advantage , but research on in medicine role mechanism also relatively weak , resulting in Chinese medicine prevention VD of objectivity , The science is not strong . No people a systematic comparison of the effect and mechanism of action of the compatibility of different therapies and combinations of prevention . Previous work , we have confirmed the clinical kidney , phlegm, blood three methods protect brain tissue , and improve the role of memory capacity . The purpose of this experiment is the whole organization and molecular level , the role of prevention in the compatibility of the different therapies and to compare and elucidate its mechanism of action , and thus reveal the etiology and pathogenesis of VD . TCM clinic will lay the foundation for the development of rational therapeutic principle , to provide a scientific basis to improve the clinical efficacy . Methods: 120 in ♂ KM Mice adaptive feeding after a week , were randomly divided into 7 groups , sham group , model group , Hydergine town group , phlegm medicine group , kidney and blood medicine group , blood circulation and resolving drug group , the kidney blood phlegm drug group . Phlegm medicine , the kidney blood medicine and blood circulation phlegm dosages are 32 g / kg, and concentration (containing crude drug ) , 3.2 g / mL ; the kidney blood phlegm dosages 40 g / kg , concentration (including crude drug ) 4.0 g / mL; Hydergine dosage of 0.77 mg / kg, with saline to a concentration of 0.077 mg / mL of the drug solution . Groups were preoperative intragastric the gavaged volume mL/100g sham group and model group fed with the same amount of Health
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