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Objective: diabetes mellitus (DM) is a common metabolic endocrine disease in our standardized prevalence rate of 3.21% , in patients with about 20 million people , rising rapidly in recent years , becoming younger age of onset . Type I diabetes mainly involving young people , the prevalence of births 0.83 , and is still growing . With the increase in diabetes malocclusion prevalence , the improvement of living standards , a growing number of diabetes patients require orthodontic treatment . However, due to the impact of diabetes on the teeth , jaw , clinical orthodontic treatment of patients with diabetes has rarely been reported . This study tooth movement model through the establishment of diabetic rats were observed in diabetic rats orthodontic tooth movement on periodontal tissue to explore early diabetic whether orthodontic tooth movement therapy , and to provide the basis of experimental theoretical basis for clinical practice . Methods : 80 male Sprague - Dawley rats , 6-8 weeks old , weighing 200-220 g , were randomly divided into two groups , the control group (normal tooth movement group ) and the experimental group (diabetes tooth movement group ) , they were divided into 5 subgroups , 0,3,7,14,21 days group , n = 8 . 72 hours after the glucose in streptozotocin (STZ) 50mg/kg intraperitoneal injection of the preparation of type I diabetes model gt ; 13.8mmol / l standard for modeling , control group was injected with the same amount of citrate buffer , after three weeks experiment. 3% sodium pentobarbital anesthesia and 3% chloral hydrate composite groups , between the left maxillary first molar and upper left central incisor into the afterburner device , traction force of 30g of the left maxillary first molar China Mobile . Were 3, 7, 14 and 21 days the afterburner before and after the afterburner take the maxillary model , the distance between the caliper measurements the first molar Tongue ditch with third molar tongue ditch point , calculated at each time point teeth the distance moved. 0,3,7,14,21 days afterburner after the rats were killed , take the left maxillary placed
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