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The Effects of Chemical Lumbar Sympathectomy in Coloproctitis and Expression of COX-2 and GFAP in Central Nervous System

Author: XuTa
Tutor: GanZiMing
School: Xinjiang Medical University
Course: Human Anatomy,Histology and Embryology
Keywords: Chemical Lumbar sympathectomy(CLS) Cyclooxygenase 2(COX2) Glial fibrillary acid protein(GFAP) central nervous system (CNS) Coloproctitis
CLC: R361
Type: Master's thesis
Year: 2005
Downloads: 47
Quote: 0
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Abstract


Objective: To study the protective effect of chemical lumbar sympathectomy on central nervous system of coloproctitis’s model rats under colon-rectum distension harm, and to offer basic medical reference for clinic use. Methods: Fifty-four Wistar rats are divided into 6 groups randomly, each group contain 9 rats. According to 2 factorial experiment design, experiment groups, experiment contrast group and control group were set up. Chemical lumbar sympathectomies were performed on coloproctitis hyperalgesia model and colon-rectum distension (CRD) was used as harm disturbing. Miampamba’s standard of evaluation for visceral pain which was divide pain into 4 grade was used to observe their behavior, repeat test for three times then record the mean value of visceromotor threshold (VMT). Finally the rats’s brain and spinal cord were take out and paraffin section were made, the medulla oblongata and spinal cord are using C0X2, the diencephalon and pons are using GFAP. The positive cells were counted by microscope. Statistic analysis was by SAS program. Results: Coloproctitis hyperalgesia and colon-rectum distension (CRD) can be smoothed by chemical lumbar sympathectomy in central nervous system(P<0.05). Coloproctitis hyperalgesia and colon-rectum distension (CRD) are not be delivered by NST, C5-8,T3-6 (P>0.05). By I to IV reflection comparing, the visceromotor threshold (VMT) didn’t combined with the sequence but the operation itself(P<0.05). False operation didn’t influence the visceromotor threshold (VMT) (P>0.05). However, operation can promote the visceromotor threshold (VMT) (P<0.05). Conclusion: Chemical lumbar sympathectomy can efficientlyprotect CNS in the process of coloproctitis’s model rat under colon-rectum distension harm, it can reduce the positive cell in CNS after CRD. The chemical lumbar sympathetic is a probably way to CNS for colo-nalgia and CRD. The CNS which was protected by CLS have nothing to do with sequence of operation, but the operation itself.

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