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Pharmaceutical Studies on Shenghuatang Oral Liquid Preparation

Author: YangHe
Tutor: SongJinChun
School: Wuhan University
Course: Pharmacy
Keywords: Biochemical soup Oral Solution Preparation Process Quality standards Preliminary stability experiments
CLC: R283
Type: Master's thesis
Year: 2005
Downloads: 237
Quote: 0
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Abstract


The \Blood circulation, temperature by analgesic efficacy, clinical for the treatment of postpartum uterine atony incomplete uterine involution cause of postpartum hemorrhage and accompanied by severe abdominal pain and other symptoms, the effect is clear. The traditional decoction existence medication large, the disadvantage of taking inconvenient, difficult to preserve, now developed into oral solution. To reduce the amount of medication on the basis of maintaining the the decoction original efficacy, convenient and easy to take and carry. In this paper, the the biochemical soup oral liquid preparation process of screening and quality standards. Research in the preparation process, through orthogonal experiment, ferulic acid content in preparation for indicators of oral liquid preparation process of the biochemical soup, the experimental results: the the biochemical soup oral liquid extraction process plus 10 (8) times the boiling water 2 times, each time 0.5h. Capillary glass tube method coagulation time and tails Determination of bleeding time Pharmacodynamics Comparative Study the biochemical soup \The results showed that the party before and after alcohol precipitation pharmacodynamic There was no significant difference (p gt; 0.01). Ethanol sediments due to the pre-experimental proof the biochemical soup room temperature viscous, the total extract up to 26.5%, affecting the clarity and stability of oral liquid, take alcohol precipitation process was refined. Single factor experimental results show that: the decoction obtained was concentrated to 1mL containing 1g crude drug, alcohol precipitation concentration of 60%. And preferably in an amount of a flavoring agent. According to the nature of the herbs, boiled, cold home, alcohol precipitation, water precipitation method to remove impurities. More effective purification methods used in this experiment to retain water extract of active ingredients, but also to ensure the stability of the preparations, shorten the production cycle, reduce costs. Quality standards research, qualitative identification and quantitative analysis of the biochemical soup oral solution. Of the biochemical soup oral solution Angelica and Chuanxiong herbs identified by thin-layer chromatography. In quantitative analysis, the establishment of a method for the determination of ferulic acid. By RP-HPLC with ferulic acid content in the sample, ferulic acid in 0.202 ~ 1.210μg range a good linear relationship (r = 0.9998), the average recovery rate was 98.41%, RSD = 1.1 %. This quantitative method is accurate and reliable, reproducible, and as a the biochemical soup oral liquid quality control method. Biochemical soup oral solution other measured indicators are in line with the \By accelerating the experiment (40 ° C, 75% relative humidity) showed that the the biochemical soup oral solution is stable.

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Chinese medicine processing,preparation
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