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Flow Rate of Micro-diffuser and Mixing Behavior of Micro-channel in Biochips

Author: ZhangBaoZhu
Tutor: WuJianKang
School: Huazhong University of Science and Technology
Course: Fluid Mechanics
Keywords: Biochip Micromixer Curved microchannel Cycle flow Microfluidic pump Diffusion tube Flow efficiency FLUENT
CLC: Q819
Type: Master's thesis
Year: 2005
Downloads: 196
Quote: 1
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Abstract


The microfluidic pump the fluid drive is a bio-chip core member. Micro-diffusion tube is one of the important parts of the valve microfluidic pump. Its structure and flow characteristics of a direct impact on the performance of the pump of the microfluidic. The biological solution and the mixing of the chemical reagents is one of the most important steps of the bio-chip analysis process, the micromixer is one of the most important parts of the bio-chip, and it directly affects the mixing effect to the analysis of the effect of the bio-chip. Therefore, the flow characteristics of the micro-diffusion tubes and micro-mixer study of great significance to the development of high-performance bio-chip. In this paper, numerical methods were studied bio-chip micro-diffusion tube and the flow characteristics of the micro-mixer, flow efficiency and liquid mixing efficiency, the paper is divided into two parts: First, the the micro diffusion tube flow characteristics and flow efficiency. The most important member as a bio-chip piezoelectric microfluidic pump, the efficiency of its flow is one of the key technologies of the microfluidic pump. In this paper, the the micro diffusion tube of rectangular cross-section flow dimensional analysis, and a large number of numerical experiments using CFD software FLUENT micro-diffusion tube liquid three-dimensional flow. The calculations show that the micro-the diffusion tube the flow diffuser tube structure geometric parameters, differential pressure, fluid properties are closely related. A large number of calculations of rectangular cross-section the diffusion tube flow efficiency with dimensionless parameters (Reynolds number, the aspect ratio of thickness to width ratio and diffusion angle) variation, as well as the efficiency of the design parameters of the optimal flow range. Second, the micro-mixer flow characteristics and liquid mixing efficiency. Investigated by numerical method the biochip curved microchannel three-dimensional periodic flow characteristics, as well as biological samples and reagents liquid diffusion in the micro-channel mixing process. Using CFD software FLUENT detailed calculation and analysis on the microchannel four flow conditions: (1) rectangular section microchannel unsteady flow; (2) rectangular section micro-channel traffic flow is not zero cycle; (3) rectangle The section bending microchannel unsteady flow; flow (4) rectangular cross-section curved microchannel flow is not zero cycle. The large number of numerical analysis results show that, in the directional flow, under the same conditions as the channel cross-section and length, from the (1) to (4) the order of the working conditions, the liquid mixing efficiency gradually improve. (4) conditions liquid mixture for maximum efficiency. The flow characteristics analysis showed that the bent micro-channel cross-sectional view of the secondary flow in a rectangular cross-section bent micro-channel flow is not zero in the current cycle, and the cycle speed of change of the flow passage cross-sectional distribution can greatly improve the efficiency of the liquid mixture.

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CLC: > Biological Sciences > Bioengineering ( Biotechnology ) > Bio-engineering applications
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