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Objective To investigate the multi-voxel ~ 1H-MRS in glioma , solitary metastases , larger differential diagnosis of brain abscess in the value of glioma tumor surrounding microstructure changes. Methods 26 cases of glioma , solitary metastases in 9 cases, 4 cases of large cerebral abscess were successful line of ~ 1H-MRS examination, comparison glioma tumor with solitary metastases and peritumoral Cho / NAA , Cho / Cr, NAA / Cr values ??differences , and do statistical analysis and HE staining , immunohistochemistry , electron microscopy to observe key changes in the microstructure of glioma week . Results at all levels glioma tumor with solitary metastases between Cho / NAA values ??were 3.14 ± 1.6l and 2.46 ± 0.83, Cho / Cr values ??were 2.57 ± 0.93 and 2.90 ± 1.93, NAA / Cr values ??were was 0.96 ± 0.53 and 1.21 ± 0.80, P values ??were greater than 0.5 , the difference was not statistically significant ; while peritumoral the ratio between 1.74 ± 0.98 and 0.98 ± 0.23,1.72 ± 0.51 and 1.09 ± 0.35,1.11 ± 0.30 and 1.11 ± 0.25, in addition to NAA / Cr were significantly outside statistically significant, P value less than 0.05 . A characteristic of brain abscess internal spectrum , DWI shows high signal on the abscess . Gliomas in light microscopy and electron microscopy has been found to tumor cell infiltration. Conclusion The use of multi- voxel ~ 1H-MRS in combination with conventional MRI can effectively identify glioma, solitary metastases , atypical brain abscess .
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