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Studies of Bisoprolol Transdermal Therapeutic System

Author: ZhangJun
Tutor: DuHongGuang
School: Beijing University of Chemical Technology
Course: Analytical Chemistry
Keywords: Bisoprolol Transdermal patch Penetration enhancers HPLC
CLC: TQ460.4
Type: Master's thesis
Year: 2006
Downloads: 136
Quote: 0
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Abstract


Bisoprolol (bisoprolol) is a novel , highly selective β 1 receptor antagonist clinically used to treat the symptoms of high blood pressure , angina , arrhythmia . Current the bisoprolol is commercially available formulations are tablets, injections , and capsules and the like, no foreign bisoprolol patch Listing . Bisoprolol has a strong pharmacological effects ( oral doses of 5 to 20mg / d ) , a small molecular weight ( 325.45 ) , and having a suitable water-soluble and higher lipophilic ( Pow logPo / W = 1.84 ) , characteristics, suitable for made of a transdermal patch . This thesis is a determination on the part of the physical and chemical properties of bisoprolol ; carried on of bisoprolol by the guinea pig back skin permeability ; and the effects of three kinds of commonly used penetration enhancers used alone or in combination of bisoprolol percutaneous infiltration . Bisoprolol transdermal patch formulation design , analysis methodology , quality standards of research and preparation of performance studies . Prescription design uses orthogonal design of system penetration enhancers , pressure-sensitive adhesive and dose selection . Experimental results show that the best prescription bisoprolol transdermal preparation : 10% of the primary dose ; the penetration enhancers Select Azone (Azone) iso- propyl ( IPM ) and the meat bean coronene acid content of 3 % The acrylic pressure-sensitive adhesive content of 40% and 10%; ; backing material is a polyester film . Bisoprolol identification methods - ultraviolet spectrophotometry ; patch content and related substances , the blood concentration of HPLC analysis method .

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