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With the continuous development of modern crushing technology and equipment crushing of traditional Chinese medicine has become an important research in the field of modernization of Chinese medicine . Reduce the particle size of the Chinese Herbal Medicine , has many advantages that improve the absorption and utilization of the active ingredients , saving medicinal resources . Crush size is too small , and may have some new problems , such as surface adsorption strengthen , affecting the absorption of the active ingredient , and may even produce some adverse reactions or side effects . Therefore , has important practical and theoretical value of Chinese medicine research of particle size . Select the rhizome of Chinese herbal medicines skullcap as the research object , using high-performance liquid chromatography (HPLC) Determination of the dissolution of its index components baicalin . Orthogonal experiment method , considering the granularity boiling , boiling time , add water and boiling the number of process parameters , and conduct research on the skullcap water boiling process . The results show that , skullcap crushed the granularity changes leaching of baicalin extract rate most significantly , the different factors that affect the degree of descending order of granularity boiling , boiling the number of times the boiling time , add water . Skullcap optimization boiling process parameters , namely the average boiling particle size of 2.5mm, the boiling time of 20 minutes , boiling for 3 times the amount of water 12 times . Skullcap on the basis of water boiling process research and select the appropriate to boiling process parameters , and study the different particle size under the conditions of the dissolution of baicalin . Found that the crush size is larger , the dissolution of baicalin increased with the size reduction ; crush size is reduced to a certain range , the dissolution of baicalin no longer with the particle size increases , but the basic remain unchanged ; baicalin dissolution with the particle size decreases when the particle size is reduced to a certain value , instead , there is an optimum particle size range . Under the present experimental conditions , Scutellaria pulverized particle size range is 1.5 ~ 2.5mm. The text is still the basis of the experimental study of the dissolution process of baicalin theoretical analysis , the reason for the existence of the particle size of the skullcap theoretically provide a theoretical basis for the establishment of the of skullcap quality control standards .
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