Dissertation > Excellent graduate degree dissertation topics show

The Circuit Design of Voltage-Clamp-Controlled Current-Clamp

Author: FanFeng
Tutor: ZuoAnLian
School: Huazhong University of Science and Technology
Course: Biophysics
Keywords: Patch-clamp amplifier Current Clamp Voltage -controlled current clamp clamp
CLC: Q-337
Type: Master's thesis
Year: 2005
Downloads: 101
Quote: 0
Read: Download Dissertation

Abstract


The birth of the patch-clamp technique electrophysiological experiments technical step onto a new level , in the field of life sciences research has been widely applied quickly . With the patch-clamp technique itself is also electrophysiological studies of development and continue to progress. But as more and more people are using patch-clamp amplifier (PCA) in current clamp mode to record rapid changes in cell voltage signal , the researchers found recorded waveform amplitude and phase distortion will occur significantly . To be able to fundamentally improve the current clamp performance , first from the circuit theory and experimental data and other aspects of the recording waveform distortion occurs because the nature and the specific occurrence of the process , through the circuit transfer function analysis , theoretically PCA current clamp mode theory flaws make the system complete explanation . Radically improve the performance of current clamp only way is to redesign the circuit structure is more reasonable , including the PCA probe substantially altered. The new current clamp circuit reference voltage follower classic structure that can achieve a real sense of the current and voltage clamp recording , so as to optimize the performance of PCA current clamp mode purposes. Experiments show that the new circuit not only successfully enhance current clamp performance , but also to maintain the original voltage clamp function and noise performance. To meet the needs of certain electrophysiological experiments clamp current clamp steady-state voltage , while the actual needs of the new current clamp circuit structure based on the design of a new PCA mode - voltage clamp -controlled current clamp mode . Circuit Test results show designed to achieve the desired vision , have practical value.

Related Dissertations

  1. Alveolar macrophages induced potassium channel in a quartz cell inflammatory response in rats,R135.2
  2. Development of a Novel Patch-Clamp Amplifier,TH789
  3. Study and Design of Photoelectric Associated Detection System for Ion Activities of Single Cell,TH776
  4. Design and Implementation of Automatic Calibration and Test in Automatic Patch-Clamp Amplifier,TH789
  5. Key Circuit Design of the Computer-Controlled Patch-Clamp Amplifier,TH789
  6. Research on the Automatic Compensation for Capacitances Transient Current in Patch-Clamp Amplifier,Q2-33
  7. Study of Membrane Capacitance Measurement Based on Network Analyzer AD5933,Q27
  8. Survey of Chinese teachers of Chinese primary and secondary schools , Lashio , northern Burma,G639.337
  9. Research on China-Myanmar relations after the Cold War,D829.337
  10. Application Research on High-speed Rapier Loom Multi-Spindle Synchronous Measuring System,TS103.337.3
  11. Analysis and Design of Weft Selector for Rapier Loom,TS103.337.3
  12. Research of Rapier Electronic Let-off System and Control Algorithm,TS103.337.3
  13. The compensation applied research of shaft loom tension control car marks,TS103.337.3
  14. Based on servo-controlled rapier weaving machine to send warp and coiling institutional research,TS103.337
  15. Research on the Control System of Electronic Dobby Rapier Weaving Machine Based on Network,TS103.337.3
  16. Application of Intelligent Control & Embedded Operation System on the Development of Hybridization Oven,Q-337
  17. The Research and Development of Electronic Let-off and Electronic Take-up System,TS103.337.3
  18. High performance rapier weft insertion and beating Design and Research,TS103.337.3
  19. High-speed air-jet looms Beating elastic dynamic analysis,TS103.337.1
  20. Research on the Key Components of the Jet Looms Based on Robust Reliability Design Optimization,TS103.337.1

CLC: > Biological Sciences > Biological science research methods and techniques > Biological experiments and biological techniques > Laboratory equipment and devices
© 2012 www.DissertationTopic.Net  Mobile