Dissertation > Excellent graduate degree dissertation topics show

Clinical Study on the Relationship between Peripheral Blood CD4～+CD25～+ Regulatory T Cells Level and Renal Transplants Long-term Survival

Author: LuCaiBao
Tutor: WuXiongFei
School: Third Military Medical University
Course: Surgery
Keywords: CD4~+CD25~+ regulatory T cell renal transplantation IL-10 TGF-β1
CLC: R699.2
Type: Master's thesis
Year: 2005
Downloads: 60
Quote: 0
Read: Download Dissertation

Abstract


Renal transplantation is an effective way to cure end-stage renal disease (ESRD). And short-term survival of renal tranplants rate (STSRTR) has significantly increased up to 90% because of the improvement of HLA-match and immunosupression .But the long-term survival rate of renal transplants (LTSRRT) still has no significantly increase and 10-year survival rate is just about 35%. That is because of chronic allograft nephropathy(CAN)and toxicity and adverse reactions of non-specificity immunosupression. Specific tolerance to allograft is the best way to reduce chronic rejection and side effects of immunosupression. There are evidences demonstrate that regulatory T cells(Tregs) are involved in the maintenance of tolerance to renal allografts and local suppressive factors are implicated in mechanism of tolerance.Among the CD4~+regulatory T cells basically two different subsets of Tregs can be differentiated by their distinct suppressive mechanisms. Naturally occurring CD4~+CD25~+Tregs exert their suppressive effects obviously via cell contact by membrane-bound molecules although the nature of these molecules is still elusive. The suppressive capacity of the second subset, Th3 and type 1 T regulatory (Tr1) cells, is contact independent and is based mainly on cytokines such as IL-10 and TGF-β1. It seems that these cells, in contrast to naturally occurring CD4~+CD25~+Tregs, represent altered states of differentiation rather than a unique cell lineage. However, the relationship between peripheral blood CD4~+CD25~+Tregs level and long-term survival is currently a matter of debate.To study relationship between peripheral blood CD4~+CD25~+Tregs level and renal transplants long-term survival and the role of IL-10 and TGF-β1.Methods:1. Detection CD4~+CD25~+Tregs level of PBL by means of FCM.

Related Dissertations

  1. Noble Dendrobium Polysaccharides Attenuate Learning and Memory Deficits Induced by Lipopolysaccharide and Its Mechanisms in Rats,R285.5
  2. Effect of Grape Seed Procyanidins on the Blood Pressure in Renovascular Hypertensive Rats and Its Mechanism,R544.1
  3. Salt-induced Vascular Remodeling and Telmisartan Intervention in Wistar Rats,R544.1
  4. Cloning and Expression Analysis of NCCRP-1 AND IL-10 Genes in Grass Carp (Ctenopharyngodon Idellus),S917.4
  5. Diagnosis Value of Cytokine Levels and TB-Ab in Serum in Children Tuberculosis and Latent Tuberculosis Infection,R725.1
  6. Effects of TGF-β1 and Sodium Butyrate on Human Colorectal Cancer Cell Line HCT-116 Proliferation,R735.34
  7. Preliminary Study on the Relationship between Non-small Cell Lung Epithelial Mesenchymal Transition and Metastasis and Its Influencing Factors,R734.2
  8. Expression and Significance of TGF-β1/Smad Signaling Pathway in Hepatic Fibrosis of Mice During the Middle Stage of Infection in Mice Infected by Echinococcus Multilocularis,R532.32
  9. The Induction of Proteins ESAT-6 and Ag85B Secreted by Mycobacterium Tuberculosis on FoxP3mRNA in Peripheral Blood,R392
  10. The Expression and Significance of TGF-β/Smad Singlling Pathway in Middle Ear Cholesteatoma,R764
  11. Effects of N-Acetylcysteine on the Expression of Transforming Growth Factor β1 in Pulmonary Fibrosis Rats,R563
  12. The Role and Mechanism of Tr1 Regulatory T Cells in Hepatic Immune Tolerance,R392
  13. Impaction on Proliferation of Rat Liver Cell Line BRL-3A Exerted by TGF-β1 or Lentivirus Expressing shRNA Trageted to Smad3 Gene,R575
  14. Effect of Prenatal Hypoxia on the Cardiac Cell-extracellular Matrix Connections and Myocardial Remodeling in Rat Offspring,R714.7
  15. Effects of Ionizing Radiation on Regulatory T Lymphocytes and the Expression of Related Molecules in Immune Organs in Mice,R392
  16. The Experimental Study of Inducing Recipient Immune Tolerance to Rat Cardiac Allografts by Injecting B7-2 mAb & CD4~+CD25~+ Regulator T Cells,R392
  17. The Measurement and Significance of the HLA Class-Ⅰ (-A, -B, -C) Expression on Peripheral Blood CD3~+/CD8~+ T-Lymphocyte Surface after Renal Transplant,R699.2
  18. Effects of Xueqitongshentang on TGF-β1/p38 MAPK Signal Transduction in Diabetic Nephropathy Rats,R285.5
  19. The Influences of TGF-β1 on the Denervated Mouse MDSCs’ Producting the CTGF in Vitro,R746.4
  20. Anti-chronic-rejection effects of herb-S and Chinese medicine Danshen in rat renal allograft,R699.2
  21. Cloning of IL-10 Gene, Wean Immune Regulatory Cytokine, and Preparation of Its Prokaryotic Recombinant Protein,R392

CLC: > Medicine, health > Surgery > Urology ( urinary and reproductive system diseases) > Urinary tract and male reproductive system surgery > Kidney surgery
© 2012 www.DissertationTopic.Net  Mobile