Dissertation > Excellent graduate degree dissertation topics show

Expression of Murine Mannose Recptor CR Domain and Primary Recerch of Interaction between CR Domain and L-selectin

Author: YuShengJin
Tutor: ZhangJiaNing
School: Dalian Medical University
Course: Biochemistry and Molecular Biology
Keywords: CR-Fc chimeric protein protein purification adhesion in vitro
CLC: R392
Type: Master's thesis
Year: 2006
Downloads: 40
Quote: 2
Read: Download Dissertation

Abstract


Mannose receptor is one of the mannose receptor family and belongs to C-type lectin receptor.Mannose receptor distributes extensively in vivo ,which is predominantly expressed on immune cells of myeloid lineage, especially subsets of dendriric cells (DC) and tissue macrophages .In addition,it is now clear that it is also expressed in hepatic sinusoidal cells, human epidermal Langerhans cells, kidney mesangial cells, subsets of endothelial cells, smooth muscles cells from the trachea and retinal pigment epithelium. A number of functions have been ascribed to mannose receptor including modulating tissue homeostasis, regulating innate immunity and adaptive immunity.In addition, mannose receptor maybe take part in tumor lymphatic pathway metastasis and tumor immune evasion in tummor microenvironment.Mannose receptor is a 175 kDa I type transmembrane receptor consisting of five domains: a cysteine rich amino terminus; a fibronectin type II repeat region; 8 calcium dependent carbohydrate recognition domains (CRDs; CRD1-8); a transmembrane domain and a cytoplasmic domain. Mannose receptor can bind endogenetic and extrinsic ligand through different domains.Cysteine rich domain is the N-terminal sequence of mannose receptor and specifically binds acidic glycans terminating in either N-acetyl- galactosamine sulphated at position 3 or 4, or 3-sulphated galactose such as those found on the pituitary hormones,lutropin (luteinizing hormone) and thyrotropin.Furthermore, it has been found a number of ligands of CR domain in lymph node such as sialoadhesin,CD45 and many ligands

Related Dissertations

  1. Purification of Recombinant Schistosoma Japonicum Protein SjGST and Preparation and Characterization of the Monoclonal Antibody,R392
  2. Cloning and Expression of Fimn Gene of Bordetella Bronchiseptica in Rabbitry and Establishment of Rapid Detection Method,S858.291
  3. Screening and Purification of Antimicrobial Peptides with Anti-tumor Cells K562 Activity from the Tenebrio Molitor Linnaeus and Experimental Study of Anti-K562 in Vitro of the Antimicrobial Peptide,R285
  4. Study on Optimization of Coupled Procedure of Superoxide Dismutase Purification and Modification,R341
  5. Expression and Purification of Protective Proteins of Mycobacterium Tuberculosis and Preparation of Monoclonal Antibodies Against Ag85B,R392
  6. The Expression of Pin1 Protein in Esophageal Cancer,R735.1
  7. Pilot Fermentation and Purification of Recombinant Ganoderma Lucidum Immunoregulatory Protein (rLZ-8),TQ461
  8. Purification and Function Study of the Anti-tumor Agent-Arresten Protein,R96
  9. The SARS-Associated Coronavirus Nucleocapsid Protein: Molecular Mechanism and Potential Antigen for Serodiagnosis of SARS,R511.9
  10. An Experimental Study of Biological Effects of Platelet-Derived Growth Factor on Vascular Histiocytes,R543
  11. The Effect of CXCR4 and EGFR on Promoting Metastasis and Invasion of Ovarian Cancer Cell and Its Application in Cancer Treatment,R737.31
  12. Molecular Characteristics and Antibody Preparation of Morphogenesis Related Protein (SMR1) in Arthrospira,Q943.2
  13. The Molecular Mechanism of Serum ALT Elevation in Mice Treated with Carbon Tetrachloride and Human ALT Isoenzymes: Molecular Cloning, Protein Expression and Purification and Related Study,R363
  14. A Study on the Gene Engineer Expression of Human Interleukin 3 Gene and Isolated and Purification Recombinant Protein,Q78
  15. The Expression, Purification and Renaturation of the Mature Peptide of hBMP-2 in E.Coli and Its Biological Activities,Q78
  16. Molecular Cell Biological Study on the Mineralization of Biodegradable Calcium Phosphate Materials,R318.08
  17. Recombinant Protein Production in Pichia Pastoris Expression System,Q786
  18. Cloning and Expression of the Fusion Protein of Murine Sperm Antigen Sp17 and Interleukin-5 and Its Immunological Contraceptive Effects,R392
  19. Study on Production of Nattokinase and hGM-CSF in Silkworm Baculovirus Expression System Using BmNPV and Its Biological Activity Analysis,Q786
  20. Gene Cloning and Function Clarification of Activator Protein from Magnaporthe Griesea.,S435.111.41
  21. Expression and Characteristic Analysis of Synthetic Human Epidermal Growth Factor and Fungal Immunomodulate Protein in Transgenic Tobacco Plant,Q943.2

CLC: > Medicine, health > Basic Medical > Medical Immunology
© 2012 www.DissertationTopic.Net  Mobile