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The Correlation of Cellular Proliferation and Apoptosis Related Factors Survivin、Bcl-2、Bax with Malignant Tumors Arising from Endometriosis

Author: ZouNa
Tutor: ZhaoJunJun
School: Dalian Medical University
Course: Pathology and Pathophysiology
Keywords: malignant tumors arising from endometriosis PCNA Apoptosis Survivin Bcl-2/Bax
CLC: R737.33
Type: Master's thesis
Year: 2006
Downloads: 134
Quote: 0
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Abstract


Objective: From cellular proliferation and apoptosis to study the relative factors in tumorigenic mechanism of carcinoma arising for endometriosis and to suggest some indicators from distinction between benign and malignant lesions.Methods: Immunohistochemistry and the TUNEL technique were used to detect the expression of some factors related cellular proliferation and apoptosis, including PCNA ,Survivin, Bcl-2, Bax, in 30 cases malignant tumors arising from endometriosis , comparing with non-malignant areas.Results:1. The expression-rate of Survivin protein in endometriosis with malignant change was apparently higher than that of endometriosis(p<0.05).2. The expression-rate of Bcl-2 protein in endometriosis with malignant change was apparently higher than that of endometriosis(p<0.05). There was no significant difference in expression-rate of Bax protein between benign and malignant lesions.3. PI, indicated by positive reaction of PCNA, and AI , indicated by TUNEL in endometriosis with malignant change were apparently higher than those in endometriosis(p<0.05).Conclusion: In endometriosis with malignant change, the expression of

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CLC: > Medicine, health > Oncology > Genitourinary tumors > Female genital tumors > Uterine tumors
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