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Effects of Qishenjiangzhiyin(QSJZY) on Insulin Sensitivity and Vascular Endotheial Function with Experimental Atherosclerosis Rats

Author: JiaAiMing
Tutor: ZhangHong
School: Dalian Medical University
Course: Traditional Chinese Medicine
Keywords: Qishenjiangzhiyin(QSJZY) atherosclerosis Insulin resistance insulin sensitivity vascular endotheial function
CLC: R285
Type: Master's thesis
Year: 2006
Downloads: 60
Quote: 0
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Abstract


Objective: To study the effects of Qishenjiangzhiyin（QSJZY） on vascular endotheial function and insulin sensitivity（IS）with experimental atherosclerosis（AS） rats induced by high fat diet. Which may futher elucidate the possible mechanism of antiatherosclerosis of QSJZY by biology-chemical methods.Methods: 24 rats were randomized into three groups. one group served as normal control group,the second group was fed with high-fat diet and ejecting with vitamin D2 served as food-induced atherosclerosis model group. the third group was fed with high-fat diet in junction with Qishenjiangzhiyin （QSJZY）. HE staining was used to study the pathology change of AS.Serum lipids, FPG, FINS, ET, 6-k–PGF1a, TXB2 were measured and ISI and TXB2/6-k–PGF1a were calculated after 6 weeks after experiment.Results:1. In treatment group , TC、LDL-C were significantly lower and HDL-C was significantly higher than those in high-fat group （P<0.01）. TG was no difference.2. In treatment group , ET、TXB2、TXB2/6-k–PGF1a were significantly lower and 6-k–PGF1a was significantly higher than those in high-fat group（P<0.01）.3. In treatment group,FPG and FINS were significantly lower and ISI was significantly higher than those in high-fat group （P<0.01）.4. The increase of ISI was corrected with the decrease of ET、TXB2、TXB2/6-k–PGF1a（r=-0.755,-0.734,-0.763. P<0.01）. While it was corrected

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