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Effects of Bean Isoflavone on the Growth of Mammary Cancer Cell Line MCF-7 and Potential Mechanisms

Author: LiuHanQiang
Tutor: WangFeng
School: Fourth Military Medical University
Course: Nutrition and Food Hygiene
Keywords: genistein daidzein mastopathia cell apoptosis cell cycle 5-FU Na2S-2O4 bcl-2 Bax Caspase-3
CLC: R737.9
Type: Master's thesis
Year: 2006
Downloads: 184
Quote: 2
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Abstract


The anti-cancer effects of non-nutritional ingredient in the food were more and more thought highly of now, especially the bean isoflavone which had benn paid most close attention to. The bean isoflavone is one of the most important non-nutritional ingredient in the bean, recently many studies have showed that the bean isoflavone posses many physiologic properties including anti-oxidation, anti-cancer, protection of heart and blood vessel system, prevention and cure of osteoporosis. ObjectiveTo study the effects of genistein and daidzein on mastopathia cell MCF-7 about growth inhibition, the cell cycle blocking,cell apoptosis inducion and potential mechanisms. MethodsIn vitro, MCF-7 cell was normally cultured, then during the cell logarithm growth period, the cells were treated by genistein and daidzein of the different dose (160、 80、40、20、10、 5.0、2.5、0.4、0.2μmol/L,1~ 4d) . The growth of the cells was examined by MTT assay; Cell morphological changes were detected by Giemsa staining and hoeschst

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