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Green and Efficient Synthesis of Tetronic Acid

Author: LiuJing
Tutor: WangGuang
School: Northeast Normal University
Course: Analytical Chemistry
Keywords: Tetronic Acid Intermediate Green Synthesis Ethyl 4-chloroacetoacetate Water
CLC: TQ251.1
Type: Master's thesis
Year: 2011
Downloads: 8
Quote: 0
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Abstract


Tetronic acid and its derivatives widely distribute not only in nature but also in our daily life, which have different types and large numbers. Tetronic acid and its derivatives are always used for the preparation of medicine, pesticide and chemical production, and they are important organic compounds with high biological and pharmacological activity. Most of the derivatives are synthesized by teronic acid, so tetronic acid is widely used as intermediate in organic synthesis. The reports on synthesis of furanone compounds are rarely in present, especially fewer for the synthesis of tetronic acid. So it is necessary to develop an efficient and feasible method for the synthesis of tetronic acid.The existing methods of synthesis tetronic acid are not so many, most of which use organic solvents and more react steps. Furthermore, the reaction conditions are more precise and also the yield is not high. Organic solvents and by-products in multi-step reaction caused serious pollution to the environment. In this research work, tetronic acid was synthesized by one-step using Ethyl 4-chloroacetoacetate as the main raw material and water as the solvent. The structure of the compound is characterized using the following means, nuclear magnetic resonance (NMR), mass spectrometry (MS), infrared spectroscopy (IR), and so on. Through the orthogonal experimental design, we investigated the effect of reaction temperature and alkali concentration on the experimental yield and optimized the synthesis conditions. Compared with the method reported in the literature, the synthesis route simplifies the process, predigests the method and raises the yield. It is an environmentally friendly synthesis method which has feature of green chemistry.

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CLC: > Industrial Technology > Chemical Industry > Basic Organic Chemistry Industry > The production of heterocyclic compounds > Five heterocycles containing a single different atoms > Oxa -mao ( furans) family
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