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Subject: The purpose of this.thesis is to explore the therapeutic mechanism of Radix Astragli injection from the point of view of modern medicine through studying its clinical therapeutic effect on patients with chronic glomerulonephritis characteristic of "qi" deficiency in lung - kindney , and its effect on urine protein, plasma albumin, plasma cholesterol, plasma creatinine, urea, hemodynamies urine (B)2-microgiobulin , T lymphocyte , plasma endothelin , nitric oxide .Method: Observe the clinical manifestation of patients of chronic glomerulonephritis characteristic of "qi" deficiency in lungs kidneys before and after the trentment with the Radix Astragali injection; Measure the urine protein, plasma albumin, plasma cholesterol, plasma creatinine, urea nitrogen, hemodynamies, urea (B)2-microgiobulin, T lymphocyte subset, plasma endothelin, nitrogen monoxide before and after the treatment.Result: Radix Astragali injection can effectively improve the clinical manifestations shown by patients of chronic glomerulonephritis (P< 0.01), decrease the urine protein (P<0.01), greatly increase the plasma albumin , decrease the plasma cholesterol (P<0.01). and decrease the urea (B)2-microgiobulin (P<0.05), It hasn’ t obvious affect on BUN & Cr, but it could decrease the urea (B)2-microgiobulin (P<0.05), improve indices of hemodynamies (P<0.05), increase OKT3, OKT8, decrease OKT4/OKT8 (P<0.05), and decrease concentration of ET and NO.conclusion : Radix Astragali injection is effective to cure chronic glomerulonephritis. It can decrease the urine protein and increase the plasma albumin, thus protect the function of glomerulus and renal tubule. The mechanism could be that Radix Astragali injection could adjust immune function of renal cell, improve hemodynamies and plasma viscosity, dcrease hyperplasia of glomerulars mesangiumexterior cellar matrix by decreasing ET (endothelin) & NO (nitric oxide) concentration.
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