Dissertation > Excellent graduate degree dissertation topics show

Liquid-Phase Organic Synthesis Using Poly (Etheylene Glycol) as Support

Author: JinJie
Tutor: ShangYongJia
School: Anhui Normal University
Course: Organic Chemistry
Keywords: Poly(ethylene glycol)(PEG4000) Liquid-Phase Organic Synthesis Knoevenagel condensation Isoxazoline
CLC: O621.3
Type: Master's thesis
Year: 2006
Downloads: 134
Quote: 0
Read: Download Dissertation

Abstract


Recently, the liquid-phase organic synthesis supported by soluble polymer was applied successfully to combinatorial chemistry and parallel synthesis. Synthetic approaches which utilize soluble polymers termed liquid-phase chemistry, couple the advantages of homogeneous solution chemistry with those of solid phase methods. Under the previous research work of our workgroup, PEG-supported piperazine was synthesized as a Knoevenagel catalyst; a series of multisubstituted acrylic acid methyl esters and isoxazolines have been synthesized in this paper. All reactions were highly efficient in giving the desired compounds in high yields by simple precipitation and wash, which suited the demand of parallel and combinatorial of small molecule libraries.Firstly, Polymer-supported piperazine, that is PEG-supported piperazine, as a Knoevenagel catalyst has been prepared and evaluated. The performance of reusing the catalyst has been studied. The result indicate that it can effectively catalyze Knoevenagel condensation and can be reused at least two times. Secondly, the polymer-supported active methylene compound perform the Knoevenagel condensation with aromatic aldehydes to give eight 2-Acetyl-3-phenylacrylic acid methyl esters. The yields were in the range of (85～98%).Thirdly, we have developed a practice and efficient liquid-phase synthetic method of 3,5-isoxazoline via 1,3-dipolar cycloaddition. PEG-supported alkene reacted with in situ generated nitrile oxides to give Eleven bisubstituted-isoxazolines. The yields were in the range of (49-91%).

Related Dissertations

  1. The Research on Knoevengal Condensation Catlyzed by the Hydrobromic Acid,O621.25
  2. Aromatic aldehydes with malononitrile solid-phase reaction mechanism of,O621.2
  3. Several Three-Component Reactions and Their Cascade Reactions,O621.3
  4. Study on the Unit Reactions of the Fine Synthesis in Ionic Liquids,TQ03
  5. Study on Functionalized Ionic Liquids and Their Applications in the Condensation Reactions,O621.252
  6. The Synthesis, Structural Analysis and Biological Activity of Novel C-Disaccharides,O629
  7. The Study on the Synthesis of Pregabalin,TQ463.2
  8. Liquid-Phase Organic Synthesis of Heterocyclic Compounds Based on Poly (Ethylene Glycol)-Supported Acetoacetate,O631.3
  9. Study on the Syntheses and Antibacterial Acticity of Metal Organic Complexes Built from Three Carboxylate Ligands,O621.13
  10. Synthesis and Characterization of Monovalent, Divalent Imidazolium Ionic Liquids Containing Hydrocarbons,O621.3
  11. Flexible,rigid,Synthesis and characterization of mixed ligand complexes,O621.1
  12. Analysis of Adsorption Mechanism of Drinking-water Defluorination Material Bio-F,O621.25
  13. Synthesis and properties of novel fluorescent probe molecules for copper, zinc or iron ion detection,O621.3
  14. Syntheses, Structures and Properties of Metal-organic Frameworks Based on Dicarboxylate Ligands,O621.13
  15. Synthesis and Reactions of Organo Lithium, Potassium, Magnesium Compounds,O621.13
  16. Synthesis and Structures of Metal (Mn, Zn and Sn) Complexes Incorporating with the Sily-linded Bis (Amidinate) Ligands,O621.2
  17. Synthesis and Characterization of Aromatic Amidinate Supramolecular and Phosphorus Imido Compounds,O621.2
  18. Reduction of Carbonyl Compounds with Ammonia-Borane in Water,O621.254.2
  19. Synthesis and Asymmetric Catalytic Behaviors of Chiral Imine and Dimines Schiff Bases,O621.3
  20. The Oxidation Mechanism and Stability Improved of Conjugated Polyunsaturated Fatty Acids,O621.25
  21. The Research on Knoevengal Condensation Catlyzed by the Hydrobromic Acid,O621.25
  22. Study on "One Pot" Allylation Reaction of Aldehydes Mediated by Indium,O621.25

CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Organic Chemistry general issues > Synthetic organic chemistry
© 2012 www.DissertationTopic.Net  Mobile