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Microbial Transformation of Ferulic Acid to Vanillin
Author: ZhengLiRong
Tutor: SunZhiHao
School: Jiangnan University
Course: Biochemical Engineering
Keywords: Rice bran oil foot Vanillin Aspergillus niger Scarlet secret volvatus is
CLC: TQ651
Type: Master's thesis
Year: 2006
Downloads: 353
Quote: 3
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Abstract
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In this thesis, Aspergillus niger ( Aspergillus niger ) CGMCC0774 and scarlet of dense hole bacteria ( Pycnoporus , cinnabarinus ) CGMCC1115 joint conversion of ferulic acid in rice bran oil foot production of vanillin research . The hydrolysis extract of rice bran oil foot ferulic acid is used as a substrate in the production of vanillin . Irradiated by 60Co Aspergillus niger ( A. niger ) SW - 33 , after screening , rescreening , and then re-screened a resistance to higher substrate concentration mutant strain of Aspergillus niger ( A. niger ) CGMCC0774 three times the average shake The bottle was converted to vanillic acid concentration of 2.481 g / L , the molar rate of 71.62% . The Aspergillus niger CGMCC0774 into vanillic acid ferulic acid to generate the optimal conditions : the transition temperature to 37 ° C , speed 150 r / min , the substrate ferulic acid concentration of 4 g / L , pH 4.0 - 4.5 , shake bottled liquid The amount of 140 mL/250 mL . Aspergillus niger CGMCC0774 into ferulic acid generated vanillic acid 15 L and 25 L fermentor scale-up , the flow of substrate vanilla acid 2.24 g / L , the molar conversion rate was 64.6% . The study is a two-step series vanillin from ferulic acid conversion process , Aspergillus niger generated conversion of ferulic acid to vanillic acid conversion solution was filtered to remove the bacterial cells , adjusted pH 5.0 , supplemented with 5 g / L glucose, sterilization , using cultured the good vermilion secret volvatus free bacterial transformation , production of vanillin 0.63 g / l . Research scarlet secret hole bacteria ( P. cinnabarinus ) separation of CGMCC1115 reaction coupled into vanillic acid concentration of 4 g / L and the amount of resin and 20 g vanillin concentration of 2.20 g / L , the molar yield of 60.69% . Obtained after purification of the subjects developed the vanillin crystalline sample 13C isotopic carbon 13C/12C ratio significantly different from Yuchuang the the lignans material chemically synthesized vanillin , with Rhovanil ? Natural ( Natural equate ) similar . Try preliminary study on scarlet secret volvatus cells immobilized into 72 h produced vanillin 0.499 g / L Immobilized cells repeatedly used four times , vanillin concentration decreased significantly , scarlet secret volvatus and immobilized needs further study .
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