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Biochip technology through the microfilm technology built on a solid substrate surface micro- biochemical analysis system , to achieve the cells, proteins , nucleic acids and other biomolecules fast, accurate, high-throughput testing. Combinatorial Material Chip technology through parallel synthesis, high-throughput characterization of the research strategy , short preparation materials library , and rapid characterization of their properties , to achieve high-throughput screening of new materials and optimization. Non-contact dispensing biochip prepared with quantitative accuracy , reproducibility and good, but easy to plug the nozzle , print samples large chip density is low. Preparation of composite material of the droplet ejection reactants chips use spotting solution and mixed , and then solvent was evaporated to solid phase reaction , the chip production efficiency is low. Nanjing University Micro Systems Laboratory invention microfluidic pulse drive - control technology can spray a variety of liquids and powders , with simple structure , low cost , high reliability, anti-clogging , high resolution and sample points . In this paper, the starting point for the study of the technique analyzes the microchannel flow characteristics of liquids and powders , micro- injection experiments carried out research, the following was achieved : microfluidics -based pulse drive - control technology , the use of piezoelectric ceramic actuator constructed biological microarray spotting system , successful completion of the microarray spotting experiments spotting diameter up to 96μm, to meet the needs of biological microarray spotting . The conventional non-contact spray bit like instrument , compared with no heat , no external pressure device , nozzle clogging , sample diameter, etc, can improve the bio -chip sample density . Based Microfluidics pulse drive - control technology, using solenoid actuator constructed Combinatorial Material Chip Spotting System , prepared by spraying powder Y203: Eu3 red light-emitting materials chips , verify that the system preparation Combinatorial Material Chip feasibility . Powder Micro- injection method and composition was compared to a spray method , no preparation of the solution or suspension , simplified preparation process , to improve production efficiency combined material chip .
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