Dissertation > Excellent graduate degree dissertation topics show

Reaction of Aminophenylbenzimidazoles and Synthesis of New Fluorescent Compounds

Author: JinZhiJin
Tutor: OuYangJie
School: Tianjin University of Technology
Course: Applied Chemistry
Keywords: Fluorescent probe Two-photon probe Nitric oxide Tumor targeting
CLC: O626.23
Type: Master's thesis
Year: 2010
Downloads: 156
Quote: 1
Read: Download Dissertation

Abstract

2 - (2 - hydroxyphenyl)-benzimidazole and its derivatives are an important class of fluorescent compounds, has a large Stokes shift, the molar extinction coefficients and high quantum yield. However, due to an amino group and the benzene ring connected to it and a carboxyl group, greatly reducing the reactive. For the development of new fluorescent probes, we will isothiocyanate esterification of 2 - (2 - hydroxy-5 - aminophenyl) benzimidazole, and further derivatization of synthetic fluorescent probes having a new function. The two-photon fluorescence probe tend to have a larger conjugated structure having a large excitation long, and can even reach a near infrared excitation, thereby reducing the short-wave excitation light on the biological tissue injuries and background biological optical interference imaging, which is a double photon fluorescent probe to become a research hotspot reason. , NO has a very important biological significance in vivo. Facilitate their direct detection of NO applied research in the field of medicine to achieve in vivo. Fluorescence detection of nitric oxide compared with the other method has the advantages of high sensitivity, good instant and simple, and the fluorescence assay and microscope combined with be able to achieve high-resolution imaging of intracellular and extracellular NO, NO in time intuitive information and space, which is the other detection methods no advantage. This thesis, the design and synthesis of new NO fluorescent probe, and their properties were studied. The traditional tumor diagnosis and treatment side effects, cause serious damage, which affects the tissue or organ function recovery in the detection and kill tumor cells while normal cells. Research and development with good selectivity, efficiency, specificity, non-toxic or low toxic side effects of new cancer diagnosis is now a hot research and target. The thesis of 2 - (2 - hydroxy-5 - aminophenyl) benzimidazole-modified, biotin and folic acid were synthesized for the tumor targeting of the targeted structural unit fluorescence probe. The main contents are as follows: 1. Improve the synthetic method of 2 - (2 - hydroxy-5 - aminophenyl) benzimidazole. 2 with 2 - (2 - hydroxy-5 - aminophenyl) benzimidazole, as raw materials through the carbon disulfide / heavy metal salt Synthesis of 2 - (2 - hydroxyphenyl) benzimidazole-isothiocyanate, the yield 78.7%; further synthesis of the three kinds of novel fluorescent compounds, and studied them with the transition metal cobalt ions, manganese ions, iron ions, copper ions and zinc ions with the front of the fluorescence properties. Synthesized a double-benzimidazole structure of two-photon fluorescence probe, and Cu (II) complexes as NO fluorescent probe nature. 4. Synthesis of biotin as the structural units of the new function of the tumor-targeting fluorescent probes and folic acid as a structural unit of tumor-targeting molecule fluorescence probe its structure was characterized by means of IR, NMR, etc., and their fluorescence properties were studied.

Related Dissertations

CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Heterocyclic compounds > Containing five pairs or more different atoms of heterocyclic > Between the two nitrogen -mao ( imidazole) and its derivatives
© 2012 www.DissertationTopic.Net Mobile