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Objective: To develop strong water absorption, excellent performance, with strong antibacterial effect of new medical dressings - SHL hydrocolloid dressing. Method: 1, using freeze-thaw cycles: a sodium carboxymethyl cellulose (CMC-Na), polyvinyl alcohol (PVA) as a water-soluble polymer material, and a certain amount of rubber, paraffin oil, a foaming agent, etc. study by orthogonal test the quality of the CMC-Na and PVA ratio of paraffin oil and rubber substrate ratio of water phase to oil phase ratio, the foaming agent and freeze-thaw cycles on the appearance of the hydrocolloid dressing, water absorption , adhesion, to thereby obtain the best preparation process parameters of the hydrocolloid dressing. 2, with reference to the relevant provisions of the pharmaceutical and medical device testing institutions develop standards and establish a quality evaluation method, from the heat, cold forming, water absorption, diffusion, permeability, pH, adhesion, etc. Comprehensive assessment the water colloidal stability and security. Reference to the People's Republic of China Pharmacopoeia 2005 edition the preparation quality standards generally, according to the requirements of the new drug registration approval approach has been studied in relation to the preparation of the traits, release, and as index skullcap in the main component baicalin content was determined by HPLC. Results: 1, the formulation of the hydrocolloid include main components: CMC-Na and PVA mass ratio of 10% and 8% (60 parts), paraffin oil and the proportion of the rubber particles was 1:2.5 (20 parts), a foaming agent The amount of 6% (4.8 parts), single freeze-thaw, the performance index of the hydrocolloid dressing, to have good hygroscopicity, the preparation requirements of the dressings. Seen from the experimental results, the preparation of heat, cold, shaping well in saline for 24 h after water absorption of up to 3.126, permeability of 0.57 kg (/ 24h · m2)), and have a certain to wet (0.4531g / 10g gelatin) and adhesion (0.690), In addition, the preparation after the absorption liquid does not spread to the periphery, with the performance of the \comply with the requirements of wound dressing slightly acidic environment. 3, the preparations for the brown sticky dressing as index baicalin release 8 h within reach 69.92 percent of the labeled amount. Conclusion 1, a new type of wound dressing hydrocolloid used for skin ulcers, surgical wounds, trauma, which can effectively absorb wound exudate, pus, while not contaminated clothing, dressings can reduce the number of replacement, is a relatively ideal wound dressing . 2, according to SHL antibacterial properties of cross-linking technology, applied physics, the freeze-thaw cycle before main drug shuanghuanglian, colloidal preparation containing syrup. 3, SHL hydrocolloid having acidic, and has a certain swellable, \The results show that, SHL has good physical and chemical properties, in line with the requirements of wound dressings. 4, Development of shuanghuanglian hydrocolloids for Shuanghuanglian increase the dosage form of choice for a more ideal, to make shuanghuanglian to be more widely used.
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