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Study on Chemical Components and Quality Standard of Radix Astragali in Xinjikang Injection

Author: GuanYanBin
Tutor: LiYongJi
School: Heilongjiang University of Traditional Chinese Medicine
Course: Pharmacy
Keywords: The Xinjikang injection Astragalus Quality standards Content determination Fingerprinting
CLC: R286.0
Type: Master's thesis
Year: 2003
Downloads: 247
Quote: 0
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Xinjikang injection is effective traditional Chinese medicine treatment of viral myocarditis , composed of Astragalus and Salvia herbs . The main ingredients of Astragalus total saponins and total flavonoids as quality evaluation only astragaloside , it is difficult to fully control the quality of Radix , will not be able to meet the requirements of TCM injections fingerprint . To Xinjikang injection in Astragalus study , the study of the chemical composition of the astragalus , through the use of silica gel column chromatography , isolated several active ingredients , in after 1 < / sup > H -NMR < sup> 13 C-NMR, MS-FAB identification Astragaloside ; of 9,10 - dimethoxy pterocarpan - 7- 0- of β- D- glucoside ; the ononin ; 2'- OH -3 ' , 4' - dimethoxy isoflavone alkyl - 7- O- of β- D- glucoside , provided for the establishment of Xinjikang injection fingerprints index components . Colorimetry a the injection of Xinjikang total saponins and total flavonoids content was determined by HPLC astragaloside content of different flavan glycosides , saponins and flavonoids of Astragalus in content to some extent reflect the the measurement results can be used as one of the basis to judge the quality of Xinjikang injection . And developed according to the characteristics of saponins the parts and flavonoids part of the fingerprint . Excel2000, the cosine of the angle and the principle of the correlation coefficient , the peaks match , calculate the similarity of the ten lots fingerprint are above 0.99 . The results show that this method can effectively control the quality of Xinjikang injection . Experimental results show that : the perfect expression through the use of TCM fingerprint and quantitative index components , both the overall characteristics of the traditional Chinese medicine , but also superior to the the western medicine single ingredient quantitative quality control mode for the injection of Xinjikang quality evaluation reliable basis .

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > In drugs > Drug identification
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