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Comparison of Nucleosides and Related Compounds in Natural and Cultured Cordyceps

Author: FanHui
Tutor: XiangJunJian；LiShaoPing
School: Jinan University
Course: Immunology
Keywords: Nucleoside Bioavailability Cordyceps Cordyceps is HPLC-MS/MS HPLC-DAD Acid hydrolysis Determine
CLC: R284
Type: Master's thesis
Year: 2006
Downloads: 376
Quote: 0
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Abstract


The entomogenous fungus Cordyceps sinensis is a parasitic Lepidoptera bat moth larvae formed. Cordyceps important edible and medicinal value of wild resources is extremely acquisition resulting in fewer and fewer resources. Artificial Cordyceps submerged fermentation substitutes and artificial Cordyceps research in recent years has made great progress, successfully developed mycelia of products on the market, so that the existing market mainly in three Cordyceps (natural Cordyceps Cordyceps , the artificially North Cordyceps) dominated. The topic is focused on the current Cordyceps quality control deficiencies in the standard evaluation method, the existing quality standards (Chinese Pharmacopoeia (2005 edition) to adenosine as an indicator) can not reflect the real quality, that natural Cordyceps confusion, artificial Cordyceps products of varying quality, good and bad, regardless of product. Nucleoside composition has been over the years as a quality control pointer to evaluate the quality of Cordyceps on the market, however, has yet to find the relative scientific identification, evaluation, three Cordyceps quality (natural Cordyceps sinensis, Cordyceps, artificial Cordyceps militaris Cordyceps) method. To this end, we have taken the study of comparative research ideas. Use of different methods of analysis, from a different point of view to compare natural Cordyceps nucleoside ingredients. We first used high-performance liquid chromatography - mass spectrometry (HPLC-MS/MS) method, a qualitative analysis of the the Cordyceps nucleoside ingredients and nucleoside analogues, 13 nucleosides and base quantitative establish a nucleoside indicators confirmed inosine, adenosine, cordycepin characteristic components, effective identification of three Cordyceps. And clarify cordycepin (Cordyceps characteristic ingredients) distribution characteristics in different Cordyceps. Then, we focused on nucleoside component is higher than the analysis Cordyceps nucleoside content the natural Cordyceps nucleoside content, while the the natural Cordyceps nucleoside content will be increased with the storage time and conditions change, cultured Cordyceps no change phenomenon theoretically Nucleoside from Cordyceps component of nuclear (acid) glycosides may be derived from the degradation of macromolecules, making the total potential (absorption) nucleoside composition is Cordyceps real active ingredient speculation . The determination of the content of the purine bases, pyrimidine bases, acid hydrolysis and HPLC-based method to compare the analysis of natural Cordyceps total potential (absorption) nucleoside ingredients different. The full text is divided into four chapters, the first chapter the nucleoside analysis methods, literature review, to make a summary of the currently nucleoside analysis method, these analysis methods and to explore the application prospects of the nucleoside component in traditional Chinese medicine as well as three Cordyceps Introduction and nucleoside overview of the status of Cordyceps quality control. This study

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Traditional Chinese medicine chemical
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