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Arterial pressure variable compliance noninvasive detection of key technology research

Author: SunXin
Tutor: LiuChangChun
School: Shandong University
Course: Biomedical Engineering
Keywords: Arterial elasticity Pressure change compliance Noninvasive Detection Cardiovascular disease
CLC: R318
Type: Master's thesis
Year: 2007
Downloads: 61
Quote: 3
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Abstract


In modern society, the high incidence of cardiovascular disease and showed an increasing trend. Once the disease, a lot of cardiovascular disease is difficult to cure, high mortality and morbidity, treatment, rehabilitation costs, a heavy burden to the patients and their families. Cardiovascular disease is a serious threat to people's life and physical health. Atherosclerotic cardiovascular disease pathological basis, a huge role in the pathological process of cardiovascular disease. As the main indicator of atherosclerotic arterial elasticity function decline both cardiovascular system function regression results and performance. Prevention and treatment of cardiovascular disease, critical to the detection of arterial elasticity. Human arterial compliance as a function with changes in blood pressure to be detected, the result is more full, true, and objectively reflect the elastic function of the artery. Non-invasive, simple means of detection arterial pressure Variable compliance testing, more conducive to medical screening of a large area of ??the crowd, is more conducive to the prevention and treatment of cardiovascular disease in community-oriented. The pressure change of arterial compliance C (p) is the most direct reflection of arterial elasticity. It can not only qualitative expression of the arterial elasticity, but also can be quantitatively described; may reflect not only an overview of the arterial elasticity, but also can reflect the details of the arterial compliance with changes in blood pressure. This paper presents the human arterial pressure change is detected by non-invasive means of compliance C (p), and around the start on its main contents are as follows: (1) To establish and calculate the human arterial pressure variable compliance C (p ) of the analysis model. In-depth study of the cycle characteristics of the human body on the basis of the establishment of the vascular system analysis model used to calculate the human circulation artery C (p). The analysis model consists of the two parts of the circuit and mathematical models. In order to facilitate the practical application of the model is a reasonable simplification, the introduction of a simplified analytical model. (2) human arterial pressure variable compliance C (p) of the non-invasive detection methods. Based on a simplified analytical model, this paper presents a non-invasive method of detection of C (p). The extraction method using a piezoelectric sensor in the human wrist radial styloid at the radial artery pressure waveform. Extract the pressure waveform smoothing and denoising, single-cycle identification, baseline drift, scaling, diastolic recognition process to obtain compliance diastolic waveform can be used to calculate the pressure change. Diastolic waveform substituting into the differential equations of the analysis model, and to define an error function ERR as the objective function, in accordance with a certain step size within a certain range to search for the optimal characteristic parameters a and b can be obtained by the compliance of the voltage variable C (p) . (3) to build an experimental system. The experimental system uses the structure of the upper and lower machine, mainly to the completion of data acquisition, control, and data analysis and processing. In this paper, based on existing hardware introduced, focusing on several key issues in the software design. (4) initial body measured experiment and its experimental results and discussions. The experimental system structures, preliminary human measured experimental comparison and analysis of experimental data to validate the detection method as well as the validity and reproducibility of the experimental system. Finally, the experimental results are discussed.

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