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Preparation and Characterization of Magnetic Nano Bio-Composite

Author: HouPeng
Tutor: WengJie
School: Southwest Jiaotong University
Course: Biomedical Engineering
Keywords: Superparamagnetic Fe3O4 nanoparticles Magnetic fiber Magnetic thin film Magnetic porous scaffolds
CLC: R318.08
Type: Master's thesis
Year: 2007
Downloads: 318
Quote: 2
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Abstract


Magnetic materials based biological study showed that the magnetic properties can significantly affect the functional status of the living cells. The nano Fe 3 O 4 due to its strong the superparamagnetic response and good biocompatibility, has been widely used in a variety of areas of biomedical. Using nano-Fe 3 O 4 superparamagnetic particles with chitin (CT), polylactic acid (PLA) composite materials were prepared by a one-dimensional to three-dimensional applications in bone tissue engineering bio-compatible magnetic nanocomposites. Firstly, using \water-based nano-Fe 3 O 4 magnetic fluid. Material characterization and biological characterization of nano-magnetic fluid. The results show that: the modifier regulation nanocrystalline magnetic Fe 3 O 4 has a stable crystal structure, good the superparamagnetic response and biocompatibility, to meet the magnetic The material in biomedical applications requirements. In this paper, chitin sol - gel principle, through the introduction of magnetic nanoparticles were prepared by magnetic chitin film. The film material characterization. The results showed that: a uniform thin film prepared by the method having good superparamagnetic magnetic response and mechanical properties, their saturation magnetization and maximum stress with the content of the magnetic particles (examine the range of 20%), increased with the increase. In this paper, electrospinning were prepared by nano-magnetic polylactic acid fiber. Fiber material characterization and degradation characterization. The results showed that: prepared by the method of nano-magnetic fiber crystal structure than its components are changed, but still has the superparamagnetic response; its mechanical properties than pure PLA fiber has been enhanced; introduction of magnetic nanoparticles makes the fibers in the phosphate buffer solution (PBS) in the degradation of mode between the degradation of the main body between the surface of the dissolution. In addition, the innovative force of a single fiber were estimated. In this paper, the the organic foam impregnation, sintering, coating method in the porous HA surface of the stent coating containing FE 3 O 4 of magnetic polylactic acid coating. Characterization of materials science and mineral apposition in vitro characterization of the magnetic bracket. The results showed that: the stent surface uniformly coated with a the magnetic polymer coating, the introduction of magnetic particles makes the mechanical strength of the coating itself enhancements. With the increase of the magnetic particles in the dressing concentration, the porosity of the stent gradually reduced, the mechanical strength of the stent decreases first and then increases. The magnet holder in the mineralization of the deposition process, the coating having holes, the HA mineral apposition channel; applied magnetic field to accelerate the degradation of the magnetic coating and making the surface of the magnetic coated to certain mineral apposition product generating mechanism to be discussed . Finally, cell culture experiments investigated the biocompatibility of various nano-magnetic composite materials. Examine the contents of cell proliferation, cell viability and cell morphology. The results showed that each magnetic composites can promote the growth of osteoblasts, its biocompatibility are substantially superior to the respective pure matrix material, when the magnetic particles when the content is too high, biocompatibility weakened.

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CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > General issues > Biomaterial
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