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Full-thickness Tissue Engineered Skin Constructed with Autogenic Bone Marrow Mesenchymal Stem Cells

Author: HeLiJuan
Tutor: PeiXueTao
School: PLA Military Academy of Medical Sciences
Course: Pathology and Pathophysiology
Keywords: Bone marrow mesenchymal stem cells Differentiation Epidermis Genuine leather Tissue engineering
CLC: R318
Type: Master's thesis
Year: 2007
Downloads: 101
Quote: 0
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Abstract


Large skin defect , the clinical use of conventional treatment methods are difficult to achieve the desired repair effect , with the development of tissue engineering technology , constructed in vitro tissue-engineered skin has become the hotspot of of skin defects transplant treatment . In recent years, with the in-depth research into stem cells as a source of seed cells provide new ideas and new ways . Bone marrow mesenchymal stem cells (bone marrow mesenchymal stem cells, BMSCs) is a class with the self-renewal and multi-directional differentiation potential of adult stem cells , into a variety of tissue cells in vitro specific conditions , differentiation , and have sources relatively easy , compared to low immunogenicity , easy amplification characteristics . Studies have shown that transplantation of BMSCs environment -dependent changes in the ability to migrate to the lesion and the corresponding cells differentiate into the body needs . Therefore , BMSCs has become a hotspot of tissue engineering and regenerative medicine research . Of this study was to investigate the feasibility of of adult BMSCs inducing conditions differentiate into epidermal cells and fibroblasts , transplantation and biomaterial composite repair nude mice full-thickness skin wounds . Experimental results show that BMSCs in vitro to epidermal cells and dermal fibroblasts directed differentiation , and -like structure of the epidermis and dermis skin substitute and collagen scaffold composite body can be formed to repair the nude mouse skin wounds , which lay a theoretical foundation to autologous BMSCs as seed cells for tissue engineering of full-thickness skin build applications , and the establishment of the technical approach and evaluation model .

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