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Purposes: (1) investigate the 18F-deoxyglucose (FDG) imaging in the evaluation of non-Hodgkin's lymphoma (NHL) early efficacy and prognostic value. (2) explore the self- 18 F-FDG imaging and CT prognostic value before and after stem cell transplantation. Materials and Methods: The first part: collecting pathological examination confirmed before treatment, after chemotherapy, after chemotherapy early (three or four-way) the line 18 F-FDG imaging of patients with NHL 64 cases, according to early after treatment 18 F-FDG SPECT findings the patients were divided into two groups: negative group (31 cases) and positive group (33 cases). 2 groups of patients with early clinical evaluation of the efficacy of the line, the progression-free survival analysis methods univariate analysis of Kaplan-Meier survival analysis Cox proportional hazards model line multivariate analysis, the and 18 F-FDG was like compared with enhanced CT results. Part II: retrospective analysis of 17 cases ASCT before or after the line 18 F-FDG imaging of patients with NHL, analysis 18 F-FDG imaging the same period CT examination results the prognostic evaluation PPV, NPV, and accuracy and, respectively, the Kaplan-Meier progression-free survival analysis. Results: Part I: negative group, 31 cases, complete remission in 26 cases, partial remission in 4 cases, progress in one cases; positive group, 33 cases, 2 cases of complete remission, partial remission in 13 cases, 4 cases not alleviate the progress of the 14 cases. Univariate analysis results show that, whether involving the knot outside the organ, the degree of malignancy, clinical stage, LDH level and 18 F-FDG SPECT findings are important prognostic factors (P lt; 0.05). 18 F-FDG imaging negative, positive group of 2-year progression-free survival rates were 68.4% and 18.2%. The COX regression therapy the early 18 F-FDG imaging results are the most powerful prognostic impact factor (P lt; 0.001). 52 patients 18 F-FDG Imaging for Predicting prognostic value superior to CT examination (P lt; 0.001) (P gt; 0.1). The second part: ASCT before 18 F-FDG imaging PPV, NPV, and accuracy were 78%, 71% and 75%, ASCT after PPV, NPV, and accuracy were 86%, 63% and 73%. The ASCT front and rear 18 F-FDG imaging negative and positive cases PFS difference was statistically significant (P lt; 0.05), while the same period in CT and prognosis was no significant correlation (P gt; 0.05). Conclusion: (1) 18 F-FDG imaging in the evaluation of the NHL early efficacy has significant advantages, the most important factor in the prognosis independent of other factors, the prognosis is better than CT. ② ASCT before and after 18 F-FDG imaging has prognostic value, and superior to CT examination.
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