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Background and Purpose pulmonary aspergillosis caused by Aspergillus infection or inhalation of Aspergillus pathogens of acute and chronic lung disease. Invasive pulmonary aspergillosis (invasive pulmonary aspergillosis, IPA) is a common type, mainly seen in immunocompromised. In the past 20 years, IPA incidence increased year by year, due to the application of chemotherapy drugs and immunosuppressants, patients with leukemia or other malignancies in patients receiving chemotherapy or bone marrow transplantation has become a common cause of death. IPA often has acute infection, the clinical features of acute exacerbation of cough, fever, shortness of breath, hemoptysis, difficulty breathing, sore throat, weight loss and other invalid for a variety of antimicrobial agents, the images change more for the different forms of pulmonary infiltrates to bronchitis is the most common; early, there may be localized or lungs multiple infiltration, often distributed around the lung fields; the lesions rapidly expanding fused into consolidation or necrosis formation of hollow, which can also form the acute Aspergillus ball. CT showed a more characteristic \the performance characteristics; Late lesions can form aspergilloma typical \The month Xingying. Diagnosis of acute IPA difficulties, most found at the autopsy. Pathological examination and fungal culture of the diseased tissue is the main method of diagnosis of invasive pulmonary aspergillosis. Specimens such as bronchoalveolar lavage fluid and bronchial attraction should smear examination and fungal culture the combination application than the cultured alone can increase the positive rate of 15% to 20%. Serum antibody detection methods for the diagnosis of IPA disease is often secondary in immunocompromised patients, and the fast development of the disease, not enough time to produce antibodies. Serum and bronchoalveolar lavage fluid antigen detection significance, serum antigen can be detected before clinical symptoms. IPA diagnosis of late, difficult to treat, the high mortality rate of almost 100% mortality without treatment, patients can survive for only part of the immune damage factors eliminated. Antifungal drug therapy and surgical treatment can improve the IPA patient survival. In this paper, collected six cases of IPA cases, observation of the summary of the diagnosis of the disease process and treatment effects, and to provide an effective method for the early diagnosis and treatment of the disease in the clinical. 【Materials and Methods】 First Affiliated Hospital of Zhengzhou University of Respiratory Medicine, July 2005-March 2007 inpatient diagnosis of IPA patients, 3 males and 3 females. Age 17 to 74 years old. Explore the experience in the diagnosis and treatment of the disease by observing the patient's symptoms, signs, laboratory tests, and drug treatment effect. 【Results】 1.6 cases the IPA of cases in five cases of fever, 6 cases of cough, sputum production, chest pain of two cases. 1 patient with lung squamous cell carcinoma, 1 patient with an adult still disease, patients with nephrotic syndrome, cases of esophageal cancer resection. 2 cases sputum culture Aspergillus, 4 cases by chest imaging characteristic changes and history and related symptoms and signs of diagnosis. 2.6 cases IPA cases were given itraconazole oral solution, and the remaining five cases itraconazole capsules oral treatment, daily doses are 400mg, divided into two doses. 6 cases were treated symptoms disappear within a week, 10 to 14 days to review the the Chest Imaging prompted lesions part absorption. The four cases were discharged after month follow-up of most of the lung lesions absorption, 2 cases were lost to follow. 【Conclusion】 1. IPA atypical clinical manifestations, confirmed to be combined with laboratory tests, chest CT imaging lesions within the cavity and the halo sign change characteristic helpful in the diagnosis. 2. The applications of itraconazole capsules or oral solution treatment IPA is a cost-effective method.
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