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Determination of Trace Elements in Blood and Speciation of Chromium in Aqueous Solution

Author: SongJuanE
Tutor: YuShui
School: PLA Military Academy of Medical Sciences
Course: Pharmaceutical Analysis
Keywords: Trace elements Carboplatin Cissy platinum Morphological analysis Inductively coupled plasma mass spectrometry (ICP-MS)
CLC: R446.1
Type: Master's thesis
Year: 2007
Downloads: 306
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Abstract


Trace elements and activities of human life is closely related to some of the essential elements of the activities of human life , while others are inert elements and even harmful elements . These elements there is a certain balance in the body content is too high or too low will cause different diseases . Meanwhile, depends largely on the physiological activity and toxicity of many trace elements in its existing form . So , how fast , accurate and easy detection of biological samples in trace elements , qualitative and quantitative determination of specific elements in the sample morphology as problems to be solved with the trace elements related fields . The papers include the following three parts : the first part of the analysis than the beagle dog plasma the antineoplastic agents carboplatin and Cissy platinum content using ICP-MS analytical technique for the determination of 20 kinds of trace elements in normal human plasma samples ; established methods; morphological analysis of chromium in water samples carried out a preliminary study . Specific content : the establishment of a fast, accurate determination of the plasma samples of 20 kinds of trace elements by ICP-MS technology and methods , analysis of 100 healthy adults and 50 healthy children, plasma samples of 20 kinds of trace elements ( Be , Mg , Cr , Mn , Co, Ni, Cu, Zn, As, Se, Mo, Ag, Cd, Sb, Ba, Hg, Tl, Pb, Th, U), gives the range of normal reference values ??. This work not only provides a variety of trace elements in the human blood fast , accurate monitoring methods at the same time provide a valuable reference data for the determination of trace elements in normal range in the plasma of the Chinese people . Rare the platinum measure of analysis method using ICP-MS technology , and for the actual determination of anticancer drugs carboplatin and of innovative drugs Cissy platinum content in the beagle dog plasma . The high sensitivity , good accuracy , the Plasma with less , so can be used for kinetic studies of carboplatin and Cissy platinum pharmacokinetics in beagle dogs . Cloud point extraction (DDTC chelating agents as Cr (Ⅲ) and Cr (Ⅵ) , Triton X-114 as extractant ) enrichment HPLC assay , conducted a preliminary study chromium speciation analysis of water samples , and the method for Determination of Cr (Ⅲ) and Cr (Ⅵ) in wastewater .

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CLC: > Medicine, health > Clinical > Diagnostics > Laboratory diagnosis > Biochemical testing, clinical testing
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