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Purpose: The purpose of this study is to explore and reveal some of the pathogenesis of hepatic fibrosis, observed Qian capsule on the prevention and treatment of liver fibrosis. Method: improved composite factor method to copy a rat model of liver fibrosis, the experimental animals were randomly divided into control group, model control group, colchicine group, the fiber capsule low dose group, high dose group of chemical fiber capsules five groups. Modeling groups to saline, colchicine suspension, low doses of chemical fiber suspension, high doses of chemical fiber suspension intervene measured in serum alanine aminotransferase enzyme (ALT), aspartate aminotransferase (AST), total bile acid (TBA) and laminin (LN), hyaluronic acid (HA), type III procollagen N-terminal peptide (P Ⅲ NP) content after HE staining light microscopy rats morphological changes in the structure of the liver tissue. Results: Compared with the control group, the model group rats serum ALT, AST, TBA, LN, HA, P Ⅲ NP content are significant with increased (P <0.01), and liver tissue morphology structure changed most significantly with; compared with the model group, colchicine group, chemical fiber, high-dose group, serum ALT, AST, TBA, LN, HA, P Ⅲ NP content were significantly lower (P <0.05 or P <0.01); compared with the colchicine group, chemical fiber low-dose group serum LN decreased more significantly (P <0.05); between the rest of the indicators of each treatment group difference was not statistically significant (P> 0.05). Colchicine group, chemical fiber, improve liver tissue lesions in varying degrees in the high-dose group, the most significant synthetic low dose group. Conclusion: chemical fiber capsules significantly reduce the serum ALT, AST, TBA's content, indicating some degree of liver protection JiangMei the role of chemical fiber capsules; Qian capsule can significantly with lower serum LN, P Ⅲ NP, HA content, show that the chemical fiber capsule has to improve the role of collagen metabolism of the body, reducing the extracellular matrix synthesis and (or) to promote the role of extracellular matrix degradation; chemical fiber capsule to some extent alleviate the liver cell degeneration, necrosis and to reduce liver tissue collagen fibers remodeling Liver ultrastructure , indicating that the chemical fiber capsules can improve liver fibrosis in rat liver tissue injury, has a certain role in the prevention and treatment of liver fibrosis. Chemical fiber capsules with colchicine compared its efficacy in some indicators than colchicine. Qian capsule low dose group compared with the high-dose group and low dose group to improve the degree of hepatic fibrosis tissue damage more significant, dose-effect relationship that the antifibrotic medicine treatment medication and the degree of lesion repair, reasonable doses of medication have been damage recovery of liver function has important value, and liver disease treatment medication should be light, to avoid the excess injury is the trial because of the degree of potential, dialectical therapy, exorcism to righting the theoretical value has been proved from the experimental point of view.
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