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The Study of Chemical Constituent Fructus Choerospondiatis

Author: TianJingMin
Tutor: LiuTao
School: Inner Mongolia Medical College
Course: Medicinal Chemistry
Keywords: Fructus choerospondiatis Chemical Constituents Structure identification
CLC: R284
Type: Master's thesis
Year: 2007
Downloads: 290
Quote: 2
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Abstract


Objective: Fructus Choerospondiatis is the dry fruit ofchoerospondias axillaris (Roxh) Burn et Hill in the members of the Anacardiaceae. Its natureand flavour are sweet,sour and mild. frutus choerospondiatis which is mainly used for the treatment of stagnation of the vital energy and blood,chest pain, palpitation and shortness of breath and irritabilitycan promotethe vital energy and blood circulation and tranquilize themind by nourishing the heart. The studies on the modern pharmacology showed that it can protect the acute myocondialischemia in the experimental mice, inhibit the experimental arrhythmia,enhance the animal hypoxia-resisted ability, reduce the platelet aggregation and effect the hemodynamics and hemorrheology. Though fructus choerospondiatis is a common mongolian drug, the studies on its chemical constituents were rarely reported in the domestic and seaside. Methods: we have extracted fructus choerospondiatis with the scientific solvent .The liquid fraction was extracted with petroleum ether that has been analyzed qualitatively quantitatively by GS/MS/DS.Other fraction was isolationed and refined with silica column chromatography, Sephadex column chromatography,thin layer chromatography, preparative thin layer chromatography. Results:eight compounds were isolated by fractional crystallization and chromatography.The structures of seven compounds have been identified as: : (1) Linoleic Acid、(2) stigmastan-7-one、(3 ) ergosterol、( 5) ursolicacid、(6)daucosterol、(7)kaempferol、(8)quercetin. Conclusion: The hexadecanoic acid, ethylester has been analyzed and identified from the liquid fraction was extracted with petroleum ether .The compounds (1)、(2)、(3)、(5) are discovered from the Fructus choerospondiatis for the first time .The result of the study provide the important scientific evidences for researches on the Pharmaco-material foundation,quality atandards of plant drug and its preparation, the clinical prescription and the development of Fructus Choerospondiatis resource.

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